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Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study
The area under the expiratory flow-volume (AEX-FV) loop has been evaluated before as a spirometric tool for assessing respiratory functional impairment. We computed the AEX-FV curves in spirometry tests performed on 20,313 participants in the National Health and Nutrition Examination Survey (NHANES)...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240334/ https://www.ncbi.nlm.nih.gov/pubmed/35190486 http://dx.doi.org/10.1136/jim-2021-002057 |
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author | Ioachimescu, Octavian C McCarthy, Kevin Stoller, James K |
author_facet | Ioachimescu, Octavian C McCarthy, Kevin Stoller, James K |
author_sort | Ioachimescu, Octavian C |
collection | PubMed |
description | The area under the expiratory flow-volume (AEX-FV) loop has been evaluated before as a spirometric tool for assessing respiratory functional impairment. We computed the AEX-FV curves in spirometry tests performed on 20,313 participants in the National Health and Nutrition Examination Survey (NHANES) study. We analyzed 108,939 spirometry tests performed between 2007 and 2012 (5964 children; 14,349 adults). In these tests, we computed the three areas from existing NHANES raw data on instantaneous expiratory flows measured at 0.01 s intervals. Mean best-trial measurements for AEX-FV were 3.4 in boys, 2.8 in girls, 11.8 in men and 7.7 L(2)/s in women. We characterized indices of central tendency and dispersion of the measurements (eg, means and fifth percentiles—lower limits of normal) by age group (children vs adults), gender, race or ethnicity group and effort grading. Simple regression equations using logarithmic transformations of the above areas and using age, gender and height as inputs provided good predictive ability for the variable AEX-FV. Regular, digital spirometry could and should make available to clinicians and researchers the area under the curves for flow versus volume graph, providing additional tools in our armamentarium to evaluate ventilatory impairments and patterns, and possibly respiratory disability. |
format | Online Article Text |
id | pubmed-9240334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-92403342022-07-11 Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study Ioachimescu, Octavian C McCarthy, Kevin Stoller, James K J Investig Med Original Research The area under the expiratory flow-volume (AEX-FV) loop has been evaluated before as a spirometric tool for assessing respiratory functional impairment. We computed the AEX-FV curves in spirometry tests performed on 20,313 participants in the National Health and Nutrition Examination Survey (NHANES) study. We analyzed 108,939 spirometry tests performed between 2007 and 2012 (5964 children; 14,349 adults). In these tests, we computed the three areas from existing NHANES raw data on instantaneous expiratory flows measured at 0.01 s intervals. Mean best-trial measurements for AEX-FV were 3.4 in boys, 2.8 in girls, 11.8 in men and 7.7 L(2)/s in women. We characterized indices of central tendency and dispersion of the measurements (eg, means and fifth percentiles—lower limits of normal) by age group (children vs adults), gender, race or ethnicity group and effort grading. Simple regression equations using logarithmic transformations of the above areas and using age, gender and height as inputs provided good predictive ability for the variable AEX-FV. Regular, digital spirometry could and should make available to clinicians and researchers the area under the curves for flow versus volume graph, providing additional tools in our armamentarium to evaluate ventilatory impairments and patterns, and possibly respiratory disability. BMJ Publishing Group 2022-06 2022-02-21 /pmc/articles/PMC9240334/ /pubmed/35190486 http://dx.doi.org/10.1136/jim-2021-002057 Text en © American Federation for Medical Research 2022. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, an indication of whether changes were made, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Ioachimescu, Octavian C McCarthy, Kevin Stoller, James K Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study |
title | Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study |
title_full | Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study |
title_fullStr | Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study |
title_full_unstemmed | Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study |
title_short | Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study |
title_sort | area under the expiratory flow-volume curve: normative values in the national health and nutrition survey (nhanes) study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240334/ https://www.ncbi.nlm.nih.gov/pubmed/35190486 http://dx.doi.org/10.1136/jim-2021-002057 |
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