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Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women

Regular exercise can regulate bone maintenance and improve bone health. However, large-scale epidemiological studies on the association between regular exercise and incident osteoporosis in menopausal women are still lacking. We aimed to examine the relationship between exercise and the risk of oste...

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Autores principales: Chang, Chu-Fen, Lee, Jia-In, Huang, Shu-Pin, Geng, Jiun-Hung, Chen, Szu-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240347/
https://www.ncbi.nlm.nih.gov/pubmed/35784236
http://dx.doi.org/10.3389/fpubh.2022.897363
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author Chang, Chu-Fen
Lee, Jia-In
Huang, Shu-Pin
Geng, Jiun-Hung
Chen, Szu-Chia
author_facet Chang, Chu-Fen
Lee, Jia-In
Huang, Shu-Pin
Geng, Jiun-Hung
Chen, Szu-Chia
author_sort Chang, Chu-Fen
collection PubMed
description Regular exercise can regulate bone maintenance and improve bone health. However, large-scale epidemiological studies on the association between regular exercise and incident osteoporosis in menopausal women are still lacking. We aimed to examine the relationship between exercise and the risk of osteoporosis in menopausal women. In cross-sectional analysis, we enrolled 30,046 postmenopausal women with available information from the database of the Taiwan Biobank (TWB). We divided them into two groups according to their status of regular exercise, i.e., no exercise and regular exercise groups. A t-score of −2.5 or more standard deviations (SDs) below that of a young adult was defined as osteoporosis. Logistic regression after adjusting for confounding factors was used to analyze the association between regular exercise and the prevalence of osteoporosis. Furthermore, the risk of incident osteoporosis development was analyzed in a longitudinal cohort of 6,785 postmenopausal women without osteoporosis at baseline using a Kaplan-Meier analysis and a log-rank test. The mean age of subjects in the cross-sectional cohort was 59 years old. Fifty-six percent of them were exercising regularly. Osteoporosis was observed in 1,886 (14.2%) and 2,254 (13.4%) participants in the no exercise and regular exercise groups. Lower risk of osteoporosis was noted in postmenopausal women with regular exercise when compared with those without regular exercise [odds ratio (OR), 0.76; 95% confidence interval (95% CI), 0.71–0.81]. In the longitudinal cohort, incident osteoporosis was found in 430 (10.5%) women with regular exercise and 299 (11.2%) women without exercise during a mean follow-up of 45 months. Cox regression analysis revealed that the risk for incident osteoporosis was lower in postmenopausal women with regular exercise than those without exercise [hazard ratio (HR), 0.83; 95% CI, 0.71–0.97]. Our study suggests that regular exercise is associated with a reduced risk of osteoporosis in postmenopausal women and strengthens the importance of exercise for the prevention of osteoporosis.
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spelling pubmed-92403472022-06-30 Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women Chang, Chu-Fen Lee, Jia-In Huang, Shu-Pin Geng, Jiun-Hung Chen, Szu-Chia Front Public Health Public Health Regular exercise can regulate bone maintenance and improve bone health. However, large-scale epidemiological studies on the association between regular exercise and incident osteoporosis in menopausal women are still lacking. We aimed to examine the relationship between exercise and the risk of osteoporosis in menopausal women. In cross-sectional analysis, we enrolled 30,046 postmenopausal women with available information from the database of the Taiwan Biobank (TWB). We divided them into two groups according to their status of regular exercise, i.e., no exercise and regular exercise groups. A t-score of −2.5 or more standard deviations (SDs) below that of a young adult was defined as osteoporosis. Logistic regression after adjusting for confounding factors was used to analyze the association between regular exercise and the prevalence of osteoporosis. Furthermore, the risk of incident osteoporosis development was analyzed in a longitudinal cohort of 6,785 postmenopausal women without osteoporosis at baseline using a Kaplan-Meier analysis and a log-rank test. The mean age of subjects in the cross-sectional cohort was 59 years old. Fifty-six percent of them were exercising regularly. Osteoporosis was observed in 1,886 (14.2%) and 2,254 (13.4%) participants in the no exercise and regular exercise groups. Lower risk of osteoporosis was noted in postmenopausal women with regular exercise when compared with those without regular exercise [odds ratio (OR), 0.76; 95% confidence interval (95% CI), 0.71–0.81]. In the longitudinal cohort, incident osteoporosis was found in 430 (10.5%) women with regular exercise and 299 (11.2%) women without exercise during a mean follow-up of 45 months. Cox regression analysis revealed that the risk for incident osteoporosis was lower in postmenopausal women with regular exercise than those without exercise [hazard ratio (HR), 0.83; 95% CI, 0.71–0.97]. Our study suggests that regular exercise is associated with a reduced risk of osteoporosis in postmenopausal women and strengthens the importance of exercise for the prevention of osteoporosis. Frontiers Media S.A. 2022-06-15 /pmc/articles/PMC9240347/ /pubmed/35784236 http://dx.doi.org/10.3389/fpubh.2022.897363 Text en Copyright © 2022 Chang, Lee, Huang, Geng and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Chang, Chu-Fen
Lee, Jia-In
Huang, Shu-Pin
Geng, Jiun-Hung
Chen, Szu-Chia
Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women
title Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women
title_full Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women
title_fullStr Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women
title_full_unstemmed Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women
title_short Regular Exercise Decreases the Risk of Osteoporosis in Postmenopausal Women
title_sort regular exercise decreases the risk of osteoporosis in postmenopausal women
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240347/
https://www.ncbi.nlm.nih.gov/pubmed/35784236
http://dx.doi.org/10.3389/fpubh.2022.897363
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