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The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease

Ventricular arrhythmia without structural heart disease is an arrhythmic disorder that occurs in structurally normal heart and no transient or reversible arrhythmia factors, such as electrolyte disorders and myocardial ischemia. Ventricular arrhythmias without structural heart disease can be induced...

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Autores principales: Wang, Mengru, Tu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240357/
https://www.ncbi.nlm.nih.gov/pubmed/35783865
http://dx.doi.org/10.3389/fcvm.2022.891399
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author Wang, Mengru
Tu, Xin
author_facet Wang, Mengru
Tu, Xin
author_sort Wang, Mengru
collection PubMed
description Ventricular arrhythmia without structural heart disease is an arrhythmic disorder that occurs in structurally normal heart and no transient or reversible arrhythmia factors, such as electrolyte disorders and myocardial ischemia. Ventricular arrhythmias without structural heart disease can be induced by multiple factors, including genetics and environment, which involve different genetic and epigenetic regulation. Familial genetic analysis reveals that cardiac ion-channel disorder and dysfunctional calcium handling are two major causes of this type of heart disease. Genome-wide association studies have identified some genetic susceptibility loci associated with ventricular tachycardia and ventricular fibrillation, yet relatively few loci associated with no structural heart disease. The effects of epigenetics on the ventricular arrhythmias susceptibility genes, involving non-coding RNAs, DNA methylation and other regulatory mechanisms, are gradually being revealed. This article aims to review the knowledge of ventricular arrhythmia without structural heart disease in genetics, and summarizes the current state of epigenetic regulation.
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spelling pubmed-92403572022-06-30 The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease Wang, Mengru Tu, Xin Front Cardiovasc Med Cardiovascular Medicine Ventricular arrhythmia without structural heart disease is an arrhythmic disorder that occurs in structurally normal heart and no transient or reversible arrhythmia factors, such as electrolyte disorders and myocardial ischemia. Ventricular arrhythmias without structural heart disease can be induced by multiple factors, including genetics and environment, which involve different genetic and epigenetic regulation. Familial genetic analysis reveals that cardiac ion-channel disorder and dysfunctional calcium handling are two major causes of this type of heart disease. Genome-wide association studies have identified some genetic susceptibility loci associated with ventricular tachycardia and ventricular fibrillation, yet relatively few loci associated with no structural heart disease. The effects of epigenetics on the ventricular arrhythmias susceptibility genes, involving non-coding RNAs, DNA methylation and other regulatory mechanisms, are gradually being revealed. This article aims to review the knowledge of ventricular arrhythmia without structural heart disease in genetics, and summarizes the current state of epigenetic regulation. Frontiers Media S.A. 2022-06-15 /pmc/articles/PMC9240357/ /pubmed/35783865 http://dx.doi.org/10.3389/fcvm.2022.891399 Text en Copyright © 2022 Wang and Tu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wang, Mengru
Tu, Xin
The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease
title The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease
title_full The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease
title_fullStr The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease
title_full_unstemmed The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease
title_short The Genetics and Epigenetics of Ventricular Arrhythmias in Patients Without Structural Heart Disease
title_sort genetics and epigenetics of ventricular arrhythmias in patients without structural heart disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240357/
https://www.ncbi.nlm.nih.gov/pubmed/35783865
http://dx.doi.org/10.3389/fcvm.2022.891399
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