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Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach

Gastric cancer (GC) is a significant cause of cancer mortality which has led to focused exploration of the pathology of GC. The advent of genome-wide analysis methods has made it possible to uncover genetic and epigenetic fluctuation such as abnormal DNA methylation in gene promoter regions that is...

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Autores principales: Vahidi, Sogand, Mirzajani, Ebrahim, Norollahi, Seyedeh Elham, Aziminezhad, Mohsen, Samadani, Ali Akbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Pharmacopuncture Institute (KPI) 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240405/
https://www.ncbi.nlm.nih.gov/pubmed/35837145
http://dx.doi.org/10.3831/KPI.2022.25.2.88
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author Vahidi, Sogand
Mirzajani, Ebrahim
Norollahi, Seyedeh Elham
Aziminezhad, Mohsen
Samadani, Ali Akbar
author_facet Vahidi, Sogand
Mirzajani, Ebrahim
Norollahi, Seyedeh Elham
Aziminezhad, Mohsen
Samadani, Ali Akbar
author_sort Vahidi, Sogand
collection PubMed
description Gastric cancer (GC) is a significant cause of cancer mortality which has led to focused exploration of the pathology of GC. The advent of genome-wide analysis methods has made it possible to uncover genetic and epigenetic fluctuation such as abnormal DNA methylation in gene promoter regions that is expected to play a key role in GC. The study of gastric malignancies requires an etiological perspective, and Helicobacter pylori (H. pylori) was identified to play a role in GC. H. pylori infection causes chronic inflammation of the gastric epithelium causing abnormal polyclonal methylation, which might raise the risk of GC. In the last two decades, various pathogenic factors by which H. pylori infection causes GC have been discovered. Abnormal DNA methylation is triggered in several genes, rendering them inactive. In GC, methylation patterns are linked to certain subtypes including microsatellite instability. Multiple cancer-related processes are more usually changed by abnormal DNA methylation than through mutations, according to current general and combined investigations. Furthermore, the amount of acquired abnormal DNA methylation is heavily linked to the chances of developing GC. Therefore, we investigated abnormal DNA methylation in GC and the link between methylation and H. pylori infection.
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spelling pubmed-92404052022-07-13 Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach Vahidi, Sogand Mirzajani, Ebrahim Norollahi, Seyedeh Elham Aziminezhad, Mohsen Samadani, Ali Akbar J Pharmacopuncture Review Article Gastric cancer (GC) is a significant cause of cancer mortality which has led to focused exploration of the pathology of GC. The advent of genome-wide analysis methods has made it possible to uncover genetic and epigenetic fluctuation such as abnormal DNA methylation in gene promoter regions that is expected to play a key role in GC. The study of gastric malignancies requires an etiological perspective, and Helicobacter pylori (H. pylori) was identified to play a role in GC. H. pylori infection causes chronic inflammation of the gastric epithelium causing abnormal polyclonal methylation, which might raise the risk of GC. In the last two decades, various pathogenic factors by which H. pylori infection causes GC have been discovered. Abnormal DNA methylation is triggered in several genes, rendering them inactive. In GC, methylation patterns are linked to certain subtypes including microsatellite instability. Multiple cancer-related processes are more usually changed by abnormal DNA methylation than through mutations, according to current general and combined investigations. Furthermore, the amount of acquired abnormal DNA methylation is heavily linked to the chances of developing GC. Therefore, we investigated abnormal DNA methylation in GC and the link between methylation and H. pylori infection. The Korean Pharmacopuncture Institute (KPI) 2022-06-30 2022-06-30 /pmc/articles/PMC9240405/ /pubmed/35837145 http://dx.doi.org/10.3831/KPI.2022.25.2.88 Text en © 2022 Korean Pharmacopuncture Institute https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vahidi, Sogand
Mirzajani, Ebrahim
Norollahi, Seyedeh Elham
Aziminezhad, Mohsen
Samadani, Ali Akbar
Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach
title Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach
title_full Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach
title_fullStr Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach
title_full_unstemmed Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach
title_short Performance of DNA Methylation on the Molecular Pathogenesis of Helicobacter pylori in Gastric Cancer; targeted therapy approach
title_sort performance of dna methylation on the molecular pathogenesis of helicobacter pylori in gastric cancer; targeted therapy approach
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240405/
https://www.ncbi.nlm.nih.gov/pubmed/35837145
http://dx.doi.org/10.3831/KPI.2022.25.2.88
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