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Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity
Introduction: The present study aimed to establish the role of lipid abnormalities and inflammatory markers for developing cardiovascular risk, as well as to address the importance of obesity as a common comorbidity in patients with obstructive sleep apnea (OSA). Methods: The study was conducted as...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240428/ https://www.ncbi.nlm.nih.gov/pubmed/35784707 http://dx.doi.org/10.3389/fphar.2022.898072 |
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author | Zdravkovic, Marija Popadic, Viseslav Klasnja, Slobodan Milic, Natasa Rajovic, Nina Divac, Anica Manojlovic, Andrea Nikolic, Novica Lukic, Filip Rasiti, Esma Mircetic, Katarina Marinkovic, Djordje Nikolic, Sofija Crnokrak, Bogdan Lisulov, Danica Popovic Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Lasica, Ratko Parapid, Biljana Djuran, Predrag Brajkovic, Milica |
author_facet | Zdravkovic, Marija Popadic, Viseslav Klasnja, Slobodan Milic, Natasa Rajovic, Nina Divac, Anica Manojlovic, Andrea Nikolic, Novica Lukic, Filip Rasiti, Esma Mircetic, Katarina Marinkovic, Djordje Nikolic, Sofija Crnokrak, Bogdan Lisulov, Danica Popovic Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Lasica, Ratko Parapid, Biljana Djuran, Predrag Brajkovic, Milica |
author_sort | Zdravkovic, Marija |
collection | PubMed |
description | Introduction: The present study aimed to establish the role of lipid abnormalities and inflammatory markers for developing cardiovascular risk, as well as to address the importance of obesity as a common comorbidity in patients with obstructive sleep apnea (OSA). Methods: The study was conducted as a prospective cohort study including 120 patients with newly diagnosed OSA between 2019 and 2020, at University Clinical Hospital Center “Bezanijska kosa”, Belgrade, Serbia. The diagnosis was established by polysomnography. In all patients, sociodemographic data, respiratory, lipid, and inflammatory parameters were collected and complete echocardiographic study and 24-h blood pressure monitoring were performed. Results: The mean patient age was 55.7 ± 13.8 years. Study population was mostly male (70.0%) and obese (56.7%). At least 30 apneas or hypopneas per hour were present in 39.0% of patients. A strong positive correlation was found between OSA severity and BMI (r = 0.562, p < 0.001), both associated with lipid, inflammatory and respiratory parameters, and cardiovascular profile of patients with OSA (p < 0.05 for all). Echocardiographic study and 24-h blood pressure monitoring parameters were in turn correlated with lipid and inflammatory markers (p < 0.05 for all). Conclusion: The results of this study support the important role of dyslipidemia and inflammation, as well as coexistence of obesity in the pathogenesis of numerous conditions linked with an increased risk of cardiovascular morbidity and mortality in patients with OSA. |
format | Online Article Text |
id | pubmed-9240428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92404282022-06-30 Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity Zdravkovic, Marija Popadic, Viseslav Klasnja, Slobodan Milic, Natasa Rajovic, Nina Divac, Anica Manojlovic, Andrea Nikolic, Novica Lukic, Filip Rasiti, Esma Mircetic, Katarina Marinkovic, Djordje Nikolic, Sofija Crnokrak, Bogdan Lisulov, Danica Popovic Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Lasica, Ratko Parapid, Biljana Djuran, Predrag Brajkovic, Milica Front Pharmacol Pharmacology Introduction: The present study aimed to establish the role of lipid abnormalities and inflammatory markers for developing cardiovascular risk, as well as to address the importance of obesity as a common comorbidity in patients with obstructive sleep apnea (OSA). Methods: The study was conducted as a prospective cohort study including 120 patients with newly diagnosed OSA between 2019 and 2020, at University Clinical Hospital Center “Bezanijska kosa”, Belgrade, Serbia. The diagnosis was established by polysomnography. In all patients, sociodemographic data, respiratory, lipid, and inflammatory parameters were collected and complete echocardiographic study and 24-h blood pressure monitoring were performed. Results: The mean patient age was 55.7 ± 13.8 years. Study population was mostly male (70.0%) and obese (56.7%). At least 30 apneas or hypopneas per hour were present in 39.0% of patients. A strong positive correlation was found between OSA severity and BMI (r = 0.562, p < 0.001), both associated with lipid, inflammatory and respiratory parameters, and cardiovascular profile of patients with OSA (p < 0.05 for all). Echocardiographic study and 24-h blood pressure monitoring parameters were in turn correlated with lipid and inflammatory markers (p < 0.05 for all). Conclusion: The results of this study support the important role of dyslipidemia and inflammation, as well as coexistence of obesity in the pathogenesis of numerous conditions linked with an increased risk of cardiovascular morbidity and mortality in patients with OSA. Frontiers Media S.A. 2022-06-15 /pmc/articles/PMC9240428/ /pubmed/35784707 http://dx.doi.org/10.3389/fphar.2022.898072 Text en Copyright © 2022 Zdravkovic, Popadic, Klasnja, Milic, Rajovic, Divac, Manojlovic, Nikolic, Lukic, Rasiti, Mircetic, Marinkovic, Nikolic, Crnokrak, Lisulov, Djurasevic, Stojkovic, Todorovic, Lasica, Parapid, Djuran and Brajkovic. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Zdravkovic, Marija Popadic, Viseslav Klasnja, Slobodan Milic, Natasa Rajovic, Nina Divac, Anica Manojlovic, Andrea Nikolic, Novica Lukic, Filip Rasiti, Esma Mircetic, Katarina Marinkovic, Djordje Nikolic, Sofija Crnokrak, Bogdan Lisulov, Danica Popovic Djurasevic, Sinisa Stojkovic, Maja Todorovic, Zoran Lasica, Ratko Parapid, Biljana Djuran, Predrag Brajkovic, Milica Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity |
title | Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity |
title_full | Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity |
title_fullStr | Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity |
title_full_unstemmed | Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity |
title_short | Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity |
title_sort | obstructive sleep apnea and cardiovascular risk: the role of dyslipidemia, inflammation, and obesity |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240428/ https://www.ncbi.nlm.nih.gov/pubmed/35784707 http://dx.doi.org/10.3389/fphar.2022.898072 |
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