Cargando…

Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes

The beneficial metabolites of the microbiome could be used as a tool for screening drugs that have the potential for the therapy of various human diseases. Narrowing down the range of beneficial metabolite candidates in specific diseases was primarily a key step for further validation in model organ...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Cheng-Yu, Wen, Qing-Feng, Wang, Qiao-Qiao, Kuang, Xia, Dong, Chuan, Deng, Zi-Xin, Guo, Feng-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240467/
https://www.ncbi.nlm.nih.gov/pubmed/35783383
http://dx.doi.org/10.3389/fmicb.2022.896740
_version_ 1784737563280408576
author Wang, Cheng-Yu
Wen, Qing-Feng
Wang, Qiao-Qiao
Kuang, Xia
Dong, Chuan
Deng, Zi-Xin
Guo, Feng-Biao
author_facet Wang, Cheng-Yu
Wen, Qing-Feng
Wang, Qiao-Qiao
Kuang, Xia
Dong, Chuan
Deng, Zi-Xin
Guo, Feng-Biao
author_sort Wang, Cheng-Yu
collection PubMed
description The beneficial metabolites of the microbiome could be used as a tool for screening drugs that have the potential for the therapy of various human diseases. Narrowing down the range of beneficial metabolite candidates in specific diseases was primarily a key step for further validation in model organisms. Herein, we proposed a reasonable hypothesis that the metabolites existing commonly in multiple beneficial (or negatively associated) bacteria might have a high probability of being effective drug candidates for specific diseases. According to this hypothesis, we screened metabolites associated with seven human diseases. For type I diabetes, 45 out of 88 screened metabolites had been reported as potential drugs in the literature. Meanwhile, 18 of these metabolites were specific to type I diabetes. Additionally, metabolite correlation could reflect disease relationships in some sense. Our results have demonstrated the potential of bioinformatics mining gut microbes' metabolites as drug candidates based on reported numerous microbe-disease associations and the Virtual Metabolic Human database. More subtle methods would be developed to ensure more accurate predictions.
format Online
Article
Text
id pubmed-9240467
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92404672022-06-30 Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes Wang, Cheng-Yu Wen, Qing-Feng Wang, Qiao-Qiao Kuang, Xia Dong, Chuan Deng, Zi-Xin Guo, Feng-Biao Front Microbiol Microbiology The beneficial metabolites of the microbiome could be used as a tool for screening drugs that have the potential for the therapy of various human diseases. Narrowing down the range of beneficial metabolite candidates in specific diseases was primarily a key step for further validation in model organisms. Herein, we proposed a reasonable hypothesis that the metabolites existing commonly in multiple beneficial (or negatively associated) bacteria might have a high probability of being effective drug candidates for specific diseases. According to this hypothesis, we screened metabolites associated with seven human diseases. For type I diabetes, 45 out of 88 screened metabolites had been reported as potential drugs in the literature. Meanwhile, 18 of these metabolites were specific to type I diabetes. Additionally, metabolite correlation could reflect disease relationships in some sense. Our results have demonstrated the potential of bioinformatics mining gut microbes' metabolites as drug candidates based on reported numerous microbe-disease associations and the Virtual Metabolic Human database. More subtle methods would be developed to ensure more accurate predictions. Frontiers Media S.A. 2022-06-15 /pmc/articles/PMC9240467/ /pubmed/35783383 http://dx.doi.org/10.3389/fmicb.2022.896740 Text en Copyright © 2022 Wang, Wen, Wang, Kuang, Dong, Deng and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Cheng-Yu
Wen, Qing-Feng
Wang, Qiao-Qiao
Kuang, Xia
Dong, Chuan
Deng, Zi-Xin
Guo, Feng-Biao
Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes
title Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes
title_full Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes
title_fullStr Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes
title_full_unstemmed Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes
title_short Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes
title_sort discovery of drug candidates for specific human disease based on natural products of gut microbes
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240467/
https://www.ncbi.nlm.nih.gov/pubmed/35783383
http://dx.doi.org/10.3389/fmicb.2022.896740
work_keys_str_mv AT wangchengyu discoveryofdrugcandidatesforspecifichumandiseasebasedonnaturalproductsofgutmicrobes
AT wenqingfeng discoveryofdrugcandidatesforspecifichumandiseasebasedonnaturalproductsofgutmicrobes
AT wangqiaoqiao discoveryofdrugcandidatesforspecifichumandiseasebasedonnaturalproductsofgutmicrobes
AT kuangxia discoveryofdrugcandidatesforspecifichumandiseasebasedonnaturalproductsofgutmicrobes
AT dongchuan discoveryofdrugcandidatesforspecifichumandiseasebasedonnaturalproductsofgutmicrobes
AT dengzixin discoveryofdrugcandidatesforspecifichumandiseasebasedonnaturalproductsofgutmicrobes
AT guofengbiao discoveryofdrugcandidatesforspecifichumandiseasebasedonnaturalproductsofgutmicrobes