Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation

RNA, like DNA and proteins, has been discovered to undergo dynamic and reversible chemical alterations, increasing the diversity and functional complexity of the molecule. N-6-methyladenosine (m(6)A) RNA methylation serves as a bridge between transcription and translation and is critical for many di...

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Detalles Bibliográficos
Autores principales: Xu, Zibin, Xie, Tingfei, Sui, Xiaolu, Xu, Yunpeng, Ji, Lecai, Zhang, Yanzi, Zhang, Aisha, Chen, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240596/
https://www.ncbi.nlm.nih.gov/pubmed/35783260
http://dx.doi.org/10.3389/fgene.2022.908289
Descripción
Sumario:RNA, like DNA and proteins, has been discovered to undergo dynamic and reversible chemical alterations, increasing the diversity and functional complexity of the molecule. N-6-methyladenosine (m(6)A) RNA methylation serves as a bridge between transcription and translation and is critical for many diseases’ progression. There is a complex interrelationship between m(6)A modifications and other epigenetic modifications. Their crosstalk significantly affects transcriptional outputs, translation, recruitment of chromatin modifiers, as well as the deployment of the m(6)A methyltransferase complex at target sites. This article outlines the potential function of m(6)A RNA methylation in epigenetics and summarizes its interactions with histone modifications.

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