Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation

RNA, like DNA and proteins, has been discovered to undergo dynamic and reversible chemical alterations, increasing the diversity and functional complexity of the molecule. N-6-methyladenosine (m(6)A) RNA methylation serves as a bridge between transcription and translation and is critical for many di...

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Autores principales: Xu, Zibin, Xie, Tingfei, Sui, Xiaolu, Xu, Yunpeng, Ji, Lecai, Zhang, Yanzi, Zhang, Aisha, Chen, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240596/
https://www.ncbi.nlm.nih.gov/pubmed/35783260
http://dx.doi.org/10.3389/fgene.2022.908289
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author Xu, Zibin
Xie, Tingfei
Sui, Xiaolu
Xu, Yunpeng
Ji, Lecai
Zhang, Yanzi
Zhang, Aisha
Chen, Jihong
author_facet Xu, Zibin
Xie, Tingfei
Sui, Xiaolu
Xu, Yunpeng
Ji, Lecai
Zhang, Yanzi
Zhang, Aisha
Chen, Jihong
author_sort Xu, Zibin
collection PubMed
description RNA, like DNA and proteins, has been discovered to undergo dynamic and reversible chemical alterations, increasing the diversity and functional complexity of the molecule. N-6-methyladenosine (m(6)A) RNA methylation serves as a bridge between transcription and translation and is critical for many diseases’ progression. There is a complex interrelationship between m(6)A modifications and other epigenetic modifications. Their crosstalk significantly affects transcriptional outputs, translation, recruitment of chromatin modifiers, as well as the deployment of the m(6)A methyltransferase complex at target sites. This article outlines the potential function of m(6)A RNA methylation in epigenetics and summarizes its interactions with histone modifications.
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spelling pubmed-92405962022-06-30 Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation Xu, Zibin Xie, Tingfei Sui, Xiaolu Xu, Yunpeng Ji, Lecai Zhang, Yanzi Zhang, Aisha Chen, Jihong Front Genet Genetics RNA, like DNA and proteins, has been discovered to undergo dynamic and reversible chemical alterations, increasing the diversity and functional complexity of the molecule. N-6-methyladenosine (m(6)A) RNA methylation serves as a bridge between transcription and translation and is critical for many diseases’ progression. There is a complex interrelationship between m(6)A modifications and other epigenetic modifications. Their crosstalk significantly affects transcriptional outputs, translation, recruitment of chromatin modifiers, as well as the deployment of the m(6)A methyltransferase complex at target sites. This article outlines the potential function of m(6)A RNA methylation in epigenetics and summarizes its interactions with histone modifications. Frontiers Media S.A. 2022-06-15 /pmc/articles/PMC9240596/ /pubmed/35783260 http://dx.doi.org/10.3389/fgene.2022.908289 Text en Copyright © 2022 Xu, Xie, Sui, Xu, Ji, Zhang, Zhang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Xu, Zibin
Xie, Tingfei
Sui, Xiaolu
Xu, Yunpeng
Ji, Lecai
Zhang, Yanzi
Zhang, Aisha
Chen, Jihong
Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation
title Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation
title_full Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation
title_fullStr Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation
title_full_unstemmed Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation
title_short Crosstalk Between Histone and m(6)A Modifications and Emerging Roles of m(6)A RNA Methylation
title_sort crosstalk between histone and m(6)a modifications and emerging roles of m(6)a rna methylation
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240596/
https://www.ncbi.nlm.nih.gov/pubmed/35783260
http://dx.doi.org/10.3389/fgene.2022.908289
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