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Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease
DNA-protein crosslinks (DPCs) are deleterious DNA lesions that occur when proteins are covalently crosslinked to the DNA by the action of variety of agents like reactive oxygen species, aldehydes and metabolites, radiation, and chemotherapeutic drugs. Unrepaired DPCs are blockades to all DNA metabol...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240642/ https://www.ncbi.nlm.nih.gov/pubmed/35782873 http://dx.doi.org/10.3389/fmolb.2022.916697 |