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Animal models of pulmonary hypertension due to left heart disease

Pulmonary hypertension due to left heart disease (PH‐LHD) is regarded as the most prevalent form of pulmonary hypertension (PH). Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease (LHD). Clinically, there are no drugs or treatments that direc...

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Autores principales: Liu, Shao‐Fei, Yan, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240728/
https://www.ncbi.nlm.nih.gov/pubmed/35234367
http://dx.doi.org/10.1002/ame2.12214
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author Liu, Shao‐Fei
Yan, Yi
author_facet Liu, Shao‐Fei
Yan, Yi
author_sort Liu, Shao‐Fei
collection PubMed
description Pulmonary hypertension due to left heart disease (PH‐LHD) is regarded as the most prevalent form of pulmonary hypertension (PH). Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease (LHD). Clinically, there are no drugs or treatments that directly address PH‐LHD, and treatment of LHD alone will not also ameliorate PH. To target the underlying physiopathological alterations of PH‐LHD and to develop novel therapeutic approaches for this population, animal models that simulate the pathophysiology of PH‐LHD are required. There are several available models for PH‐LHD that have been successfully employed in rodents or large animals by artificially provoking an elevated pressure load on the left heart, which by transduction elicits an escalated pressure in pulmonary artery. In addition, metabolic derangement combined with aortic banding or vascular endothelial growth factor receptor antagonist is also currently applied to reproduce the phenotype of PH‐LHD. As of today, none of the animal models exactly recapitulates the condition of patients with PH‐LHD. Nevertheless, the selection of an appropriate animal model is essential in basic and translational studies of PH‐LHD. Therefore, this review will summarize the characteristics of each PH‐LHD animal model and discuss the advantages and limitations of the different models.
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spelling pubmed-92407282022-07-01 Animal models of pulmonary hypertension due to left heart disease Liu, Shao‐Fei Yan, Yi Animal Model Exp Med Themed Section: Cardiovascular Disease Pulmonary hypertension due to left heart disease (PH‐LHD) is regarded as the most prevalent form of pulmonary hypertension (PH). Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease (LHD). Clinically, there are no drugs or treatments that directly address PH‐LHD, and treatment of LHD alone will not also ameliorate PH. To target the underlying physiopathological alterations of PH‐LHD and to develop novel therapeutic approaches for this population, animal models that simulate the pathophysiology of PH‐LHD are required. There are several available models for PH‐LHD that have been successfully employed in rodents or large animals by artificially provoking an elevated pressure load on the left heart, which by transduction elicits an escalated pressure in pulmonary artery. In addition, metabolic derangement combined with aortic banding or vascular endothelial growth factor receptor antagonist is also currently applied to reproduce the phenotype of PH‐LHD. As of today, none of the animal models exactly recapitulates the condition of patients with PH‐LHD. Nevertheless, the selection of an appropriate animal model is essential in basic and translational studies of PH‐LHD. Therefore, this review will summarize the characteristics of each PH‐LHD animal model and discuss the advantages and limitations of the different models. John Wiley and Sons Inc. 2022-02-09 /pmc/articles/PMC9240728/ /pubmed/35234367 http://dx.doi.org/10.1002/ame2.12214 Text en © 2022 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Themed Section: Cardiovascular Disease
Liu, Shao‐Fei
Yan, Yi
Animal models of pulmonary hypertension due to left heart disease
title Animal models of pulmonary hypertension due to left heart disease
title_full Animal models of pulmonary hypertension due to left heart disease
title_fullStr Animal models of pulmonary hypertension due to left heart disease
title_full_unstemmed Animal models of pulmonary hypertension due to left heart disease
title_short Animal models of pulmonary hypertension due to left heart disease
title_sort animal models of pulmonary hypertension due to left heart disease
topic Themed Section: Cardiovascular Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240728/
https://www.ncbi.nlm.nih.gov/pubmed/35234367
http://dx.doi.org/10.1002/ame2.12214
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