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Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans

Morphine is a widely used analgesic, but its use in clinical precision medicine is limited by the variance in response among individuals. Although previous studies have shown that individual differences in morphine can be explained in terms of pharmacodynamics and pharmacokinetics, genetic polymorph...

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Detalles Bibliográficos
Autores principales: Yang, Yin, Guan, Bowen, Wei, Qiang, Wang, Wei, Meng, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240740/
https://www.ncbi.nlm.nih.gov/pubmed/35656737
http://dx.doi.org/10.1002/ame2.12234
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author Yang, Yin
Guan, Bowen
Wei, Qiang
Wang, Wei
Meng, Aimin
author_facet Yang, Yin
Guan, Bowen
Wei, Qiang
Wang, Wei
Meng, Aimin
author_sort Yang, Yin
collection PubMed
description Morphine is a widely used analgesic, but its use in clinical precision medicine is limited by the variance in response among individuals. Although previous studies have shown that individual differences in morphine can be explained in terms of pharmacodynamics and pharmacokinetics, genetic polymorphisms also play an important role. However, the genetic basis of different sensitivity and tolerance susceptibility to morphine remains ambiguous. Using 15 strains of inbred Genetic Diversity (GD) mice, a new resource with wide genetic and phenotypic variation, we demonstrated great variance in sensitivity to morphine analgesia and susceptibility to morphine tolerance between different GD strains. Among‐individual variance in response to morphine analgesia in the population can be modeled in GD mice. Two loci respectively may be associated with the among‐individual variance in morphine sensitivity and tolerance, confirming the role of genetic factors in among‐individual different responses to morphine. These results indicate that GD mice may be a potential tool for the identification of new biomarkers to improve the clinical administration of morphine.
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spelling pubmed-92407402022-07-01 Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans Yang, Yin Guan, Bowen Wei, Qiang Wang, Wei Meng, Aimin Animal Model Exp Med Regular Articles Morphine is a widely used analgesic, but its use in clinical precision medicine is limited by the variance in response among individuals. Although previous studies have shown that individual differences in morphine can be explained in terms of pharmacodynamics and pharmacokinetics, genetic polymorphisms also play an important role. However, the genetic basis of different sensitivity and tolerance susceptibility to morphine remains ambiguous. Using 15 strains of inbred Genetic Diversity (GD) mice, a new resource with wide genetic and phenotypic variation, we demonstrated great variance in sensitivity to morphine analgesia and susceptibility to morphine tolerance between different GD strains. Among‐individual variance in response to morphine analgesia in the population can be modeled in GD mice. Two loci respectively may be associated with the among‐individual variance in morphine sensitivity and tolerance, confirming the role of genetic factors in among‐individual different responses to morphine. These results indicate that GD mice may be a potential tool for the identification of new biomarkers to improve the clinical administration of morphine. John Wiley and Sons Inc. 2022-06-03 /pmc/articles/PMC9240740/ /pubmed/35656737 http://dx.doi.org/10.1002/ame2.12234 Text en © 2022 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Regular Articles
Yang, Yin
Guan, Bowen
Wei, Qiang
Wang, Wei
Meng, Aimin
Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans
title Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans
title_full Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans
title_fullStr Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans
title_full_unstemmed Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans
title_short Morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans
title_sort morphine analgesia in male inbred genetic diversity mice recapitulates the among‐individual variance in response to morphine in humans
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240740/
https://www.ncbi.nlm.nih.gov/pubmed/35656737
http://dx.doi.org/10.1002/ame2.12234
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