Cargando…

Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes

We investigated the benefit from introgression of external lines into a cereal breeding programme and strategies that accelerated introgression of the favourable alleles while minimising linkage drag using stochastic computer simulation. We simulated genomic selection for disease resistance and grai...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yongjun, Shi, Fan, Lin, Zibei, Robinson, Hannah, Moody, David, Rattey, Allan, Godoy, Jayfred, Mullan, Daniel, Keeble-Gagnere, Gabriel, Hayden, Matthew J., Tibbits, Josquin F. G., Daetwyler, Hans D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240786/
https://www.ncbi.nlm.nih.gov/pubmed/35783964
http://dx.doi.org/10.3389/fpls.2022.786452
_version_ 1784737646694629376
author Li, Yongjun
Shi, Fan
Lin, Zibei
Robinson, Hannah
Moody, David
Rattey, Allan
Godoy, Jayfred
Mullan, Daniel
Keeble-Gagnere, Gabriel
Hayden, Matthew J.
Tibbits, Josquin F. G.
Daetwyler, Hans D.
author_facet Li, Yongjun
Shi, Fan
Lin, Zibei
Robinson, Hannah
Moody, David
Rattey, Allan
Godoy, Jayfred
Mullan, Daniel
Keeble-Gagnere, Gabriel
Hayden, Matthew J.
Tibbits, Josquin F. G.
Daetwyler, Hans D.
author_sort Li, Yongjun
collection PubMed
description We investigated the benefit from introgression of external lines into a cereal breeding programme and strategies that accelerated introgression of the favourable alleles while minimising linkage drag using stochastic computer simulation. We simulated genomic selection for disease resistance and grain yield in two environments with a high level of genotype-by-environment interaction (G × E) for the latter trait, using genomic data of a historical barley breeding programme as the base generation. Two populations (existing and external) were created from this base population with different allele frequencies for few (N = 10) major and many (N ~ 990) minor simulated disease quantitative trait loci (QTL). The major disease QTL only existed in the external population and lines from the external population were introgressed into the existing population which had minor disease QTL with low, medium and high allele frequencies. The study revealed that the benefit of introgression depended on the level of genetic variation for the target trait in the existing cereal breeding programme. Introgression of external resources into the existing population was beneficial only when the existing population lacked variation in disease resistance or when minor disease QTL were already at medium or high frequency. When minor disease QTL were at low frequencies, no extra genetic gain was achieved from introgression. More benefit in the disease trait was obtained from the introgression if the major disease QTL had larger effect sizes, more selection emphasis was applied on disease resistance, or more external lines were introgressed. While our strategies to increase introgression of major disease QTL were generally successful, most were not able to completely avoid negative impacts on selection for grain yield with the only exception being when major introgression QTL effects were very large. Breeding programmes are advised to carefully consider the level of genetic variation in a trait available in their breeding programme before deciding to introgress germplasms.
format Online
Article
Text
id pubmed-9240786
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92407862022-06-30 Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes Li, Yongjun Shi, Fan Lin, Zibei Robinson, Hannah Moody, David Rattey, Allan Godoy, Jayfred Mullan, Daniel Keeble-Gagnere, Gabriel Hayden, Matthew J. Tibbits, Josquin F. G. Daetwyler, Hans D. Front Plant Sci Plant Science We investigated the benefit from introgression of external lines into a cereal breeding programme and strategies that accelerated introgression of the favourable alleles while minimising linkage drag using stochastic computer simulation. We simulated genomic selection for disease resistance and grain yield in two environments with a high level of genotype-by-environment interaction (G × E) for the latter trait, using genomic data of a historical barley breeding programme as the base generation. Two populations (existing and external) were created from this base population with different allele frequencies for few (N = 10) major and many (N ~ 990) minor simulated disease quantitative trait loci (QTL). The major disease QTL only existed in the external population and lines from the external population were introgressed into the existing population which had minor disease QTL with low, medium and high allele frequencies. The study revealed that the benefit of introgression depended on the level of genetic variation for the target trait in the existing cereal breeding programme. Introgression of external resources into the existing population was beneficial only when the existing population lacked variation in disease resistance or when minor disease QTL were already at medium or high frequency. When minor disease QTL were at low frequencies, no extra genetic gain was achieved from introgression. More benefit in the disease trait was obtained from the introgression if the major disease QTL had larger effect sizes, more selection emphasis was applied on disease resistance, or more external lines were introgressed. While our strategies to increase introgression of major disease QTL were generally successful, most were not able to completely avoid negative impacts on selection for grain yield with the only exception being when major introgression QTL effects were very large. Breeding programmes are advised to carefully consider the level of genetic variation in a trait available in their breeding programme before deciding to introgress germplasms. Frontiers Media S.A. 2022-06-15 /pmc/articles/PMC9240786/ /pubmed/35783964 http://dx.doi.org/10.3389/fpls.2022.786452 Text en Copyright © 2022 Li, Shi, Lin, Robinson, Moody, Rattey, Godoy, Mullan, Keeble-Gagnere, Hayden, Tibbits and Daetwyler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Li, Yongjun
Shi, Fan
Lin, Zibei
Robinson, Hannah
Moody, David
Rattey, Allan
Godoy, Jayfred
Mullan, Daniel
Keeble-Gagnere, Gabriel
Hayden, Matthew J.
Tibbits, Josquin F. G.
Daetwyler, Hans D.
Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes
title Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes
title_full Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes
title_fullStr Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes
title_full_unstemmed Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes
title_short Benefit of Introgression Depends on Level of Genetic Trait Variation in Cereal Breeding Programmes
title_sort benefit of introgression depends on level of genetic trait variation in cereal breeding programmes
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240786/
https://www.ncbi.nlm.nih.gov/pubmed/35783964
http://dx.doi.org/10.3389/fpls.2022.786452
work_keys_str_mv AT liyongjun benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT shifan benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT linzibei benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT robinsonhannah benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT moodydavid benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT ratteyallan benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT godoyjayfred benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT mullandaniel benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT keeblegagneregabriel benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT haydenmatthewj benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT tibbitsjosquinfg benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes
AT daetwylerhansd benefitofintrogressiondependsonlevelofgenetictraitvariationincerealbreedingprogrammes