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Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study
INTRODUCTION: Although cannabis is frequently used worldwide, its impact on respiratory health is characterised by controversy. OBJECTIVE: To evaluate the association between cannabis use and respiratory-related emergency room (ER) visits and hospitalisations. METHODS: A retrospective, population-ba...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240874/ https://www.ncbi.nlm.nih.gov/pubmed/35760496 http://dx.doi.org/10.1136/bmjresp-2022-001216 |
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author | Vozoris, Nicholas T Zhu, Jingqin Ryan, Clodagh M Chow, Chung-Wai To, Teresa |
author_facet | Vozoris, Nicholas T Zhu, Jingqin Ryan, Clodagh M Chow, Chung-Wai To, Teresa |
author_sort | Vozoris, Nicholas T |
collection | PubMed |
description | INTRODUCTION: Although cannabis is frequently used worldwide, its impact on respiratory health is characterised by controversy. OBJECTIVE: To evaluate the association between cannabis use and respiratory-related emergency room (ER) visits and hospitalisations. METHODS: A retrospective, population-based, cohort study was carried out, linking health survey and health administrative data for residents of Ontario, Canada, aged 12–65 years, between January 2009 and December 2015. Individuals self-reporting cannabis use within the past year were matched to control individuals (people who reported never using cannabis, or used cannabis only once, and more than 12 months ago) in upwards of a 1:3 ratio on 31 different variables, using propensity score matching methods. Respiratory-related and all-cause ER visits or hospitalisations, and all-cause mortality, were evaluated up to 12 months following the index date. RESULTS: We identified 35 114 individuals who had either used cannabis in the past year or were controls, of whom 6425 (18.3%) used cannabis in the past year. From this group, 4807 (74.8%) were propensity-score matched to 10 395 control individuals. In the propensity score matched cohort, there was no significant difference in odds of respiratory-related ER visit or hospitalisation between cannabis users and the control group (OR 0.91, 95% CI 0.77 to 1.09). Compared with control individuals, cannabis users had significantly increased odds of all-cause ER visit or hospitalisation (OR 1.22, 95% CI 1.13 to 1.31) and there was no significant difference with respect to all-cause mortality (OR 0.99, 95% CI 0.49 to 2.02). CONCLUSIONS: Although no significant association was observed between cannabis use and respiratory-related ER visits or hospitalisations, the risk of an equally important morbidity outcome, all-cause ER visit or hospitalisation, was significantly greater among cannabis users than among control individuals. Therefore, cannabis use is associated with increased risk for serious adverse health events and its recreational consumption is not benign. |
format | Online Article Text |
id | pubmed-9240874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-92408742022-07-20 Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study Vozoris, Nicholas T Zhu, Jingqin Ryan, Clodagh M Chow, Chung-Wai To, Teresa BMJ Open Respir Res Smoking INTRODUCTION: Although cannabis is frequently used worldwide, its impact on respiratory health is characterised by controversy. OBJECTIVE: To evaluate the association between cannabis use and respiratory-related emergency room (ER) visits and hospitalisations. METHODS: A retrospective, population-based, cohort study was carried out, linking health survey and health administrative data for residents of Ontario, Canada, aged 12–65 years, between January 2009 and December 2015. Individuals self-reporting cannabis use within the past year were matched to control individuals (people who reported never using cannabis, or used cannabis only once, and more than 12 months ago) in upwards of a 1:3 ratio on 31 different variables, using propensity score matching methods. Respiratory-related and all-cause ER visits or hospitalisations, and all-cause mortality, were evaluated up to 12 months following the index date. RESULTS: We identified 35 114 individuals who had either used cannabis in the past year or were controls, of whom 6425 (18.3%) used cannabis in the past year. From this group, 4807 (74.8%) were propensity-score matched to 10 395 control individuals. In the propensity score matched cohort, there was no significant difference in odds of respiratory-related ER visit or hospitalisation between cannabis users and the control group (OR 0.91, 95% CI 0.77 to 1.09). Compared with control individuals, cannabis users had significantly increased odds of all-cause ER visit or hospitalisation (OR 1.22, 95% CI 1.13 to 1.31) and there was no significant difference with respect to all-cause mortality (OR 0.99, 95% CI 0.49 to 2.02). CONCLUSIONS: Although no significant association was observed between cannabis use and respiratory-related ER visits or hospitalisations, the risk of an equally important morbidity outcome, all-cause ER visit or hospitalisation, was significantly greater among cannabis users than among control individuals. Therefore, cannabis use is associated with increased risk for serious adverse health events and its recreational consumption is not benign. BMJ Publishing Group 2022-05-19 /pmc/articles/PMC9240874/ /pubmed/35760496 http://dx.doi.org/10.1136/bmjresp-2022-001216 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Smoking Vozoris, Nicholas T Zhu, Jingqin Ryan, Clodagh M Chow, Chung-Wai To, Teresa Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study |
title | Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study |
title_full | Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study |
title_fullStr | Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study |
title_full_unstemmed | Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study |
title_short | Cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study |
title_sort | cannabis use and risks of respiratory and all-cause morbidity and mortality: a population-based, data-linkage, cohort study |
topic | Smoking |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240874/ https://www.ncbi.nlm.nih.gov/pubmed/35760496 http://dx.doi.org/10.1136/bmjresp-2022-001216 |
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