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The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection()
BACKGROUND: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium <135 mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20–37% according to the series, but there are no data on the prognosis after correction of hyponatremi...
Autores principales: | , , , , , , , , , , |
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格式: | Online Artículo Texto |
語言: | English |
出版: |
Elsevier España, S.L.U.
2022
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主題: | |
在線閱讀: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240945/ https://www.ncbi.nlm.nih.gov/pubmed/35784827 http://dx.doi.org/10.1016/j.medcle.2021.07.021 |
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author | de La Flor, José C. Gomez-Berrocal, Ana Marschall, Alexander Valga, Francisco Linares, Tania Albarracin, Cristina Ruiz, Elisa Gallegos, Gioconda Gómez, Alberto de los Santos, Andrea Rodeles, Miguel |
author_facet | de La Flor, José C. Gomez-Berrocal, Ana Marschall, Alexander Valga, Francisco Linares, Tania Albarracin, Cristina Ruiz, Elisa Gallegos, Gioconda Gómez, Alberto de los Santos, Andrea Rodeles, Miguel |
author_sort | de La Flor, José C. |
collection | PubMed |
description | BACKGROUND: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium <135 mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20–37% according to the series, but there are no data on the prognosis after correction of hyponatremia. Therefore, our objectives were: to analyse the incidence and severity of hyponatremia at hospital admission, and to determine the association of this hyponatremia with the prognosis of COVID-19. METHODS: Observational and retrospective cohort study. Patients who were admitted with a diagnosis of COVID-19 infection and hyponatremia, in the period March-May 2020, were included. We recorded epidemiological, demographic, clinical, biochemical, and radiological variables of SARS-CoV-2 infection and hyponatremia at the time of diagnosis and during hospitalization. The clinical follow-up ranged from admission to death or discharge. RESULTS: 91 patients (21.8%) of the 414 admitted for SARS-CoV-2 infection presented hyponatremia (81.32% mild hyponatremia, 9.89% moderate and 8.79% severe). The absence of correction of hyponatremia 72–96 h after hospital admission was associated with higher mortality in patients with COVID-19 (Odds Ratio 0.165; 95% confidence interval: 0.018−0.686; p = 0.011). 19 patients (20.9%) died. An increase in mortality was observed in patients with severe hyponatremia compared with moderate and mild hyponatremia during hospital admission (37.5% versus 11.1% versus 8.1%, p = 0.041). CONCLUSION: We conclude that persistence of hyponatremia at 72–96 h of hospital admission was associated with higher mortality in patients with SARS-Cov-2. |
format | Online Article Text |
id | pubmed-9240945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier España, S.L.U. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92409452022-06-29 The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection() de La Flor, José C. Gomez-Berrocal, Ana Marschall, Alexander Valga, Francisco Linares, Tania Albarracin, Cristina Ruiz, Elisa Gallegos, Gioconda Gómez, Alberto de los Santos, Andrea Rodeles, Miguel Med Clin (Engl Ed) Original Article BACKGROUND: SARS-CoV-2 infection is frequently associated with hyponatremia (plasma sodium <135 mmol/L), being associated with a worse prognosis. The incidence of hyponatremia is estimated to be 20–37% according to the series, but there are no data on the prognosis after correction of hyponatremia. Therefore, our objectives were: to analyse the incidence and severity of hyponatremia at hospital admission, and to determine the association of this hyponatremia with the prognosis of COVID-19. METHODS: Observational and retrospective cohort study. Patients who were admitted with a diagnosis of COVID-19 infection and hyponatremia, in the period March-May 2020, were included. We recorded epidemiological, demographic, clinical, biochemical, and radiological variables of SARS-CoV-2 infection and hyponatremia at the time of diagnosis and during hospitalization. The clinical follow-up ranged from admission to death or discharge. RESULTS: 91 patients (21.8%) of the 414 admitted for SARS-CoV-2 infection presented hyponatremia (81.32% mild hyponatremia, 9.89% moderate and 8.79% severe). The absence of correction of hyponatremia 72–96 h after hospital admission was associated with higher mortality in patients with COVID-19 (Odds Ratio 0.165; 95% confidence interval: 0.018−0.686; p = 0.011). 19 patients (20.9%) died. An increase in mortality was observed in patients with severe hyponatremia compared with moderate and mild hyponatremia during hospital admission (37.5% versus 11.1% versus 8.1%, p = 0.041). CONCLUSION: We conclude that persistence of hyponatremia at 72–96 h of hospital admission was associated with higher mortality in patients with SARS-Cov-2. Elsevier España, S.L.U. 2022-07-08 2022-06-29 /pmc/articles/PMC9240945/ /pubmed/35784827 http://dx.doi.org/10.1016/j.medcle.2021.07.021 Text en © 2021 Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article de La Flor, José C. Gomez-Berrocal, Ana Marschall, Alexander Valga, Francisco Linares, Tania Albarracin, Cristina Ruiz, Elisa Gallegos, Gioconda Gómez, Alberto de los Santos, Andrea Rodeles, Miguel The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection() |
title | The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection() |
title_full | The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection() |
title_fullStr | The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection() |
title_full_unstemmed | The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection() |
title_short | The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection() |
title_sort | impact of the correction of hyponatremia during hospital admission on the prognosis of sars-cov-2 infection() |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240945/ https://www.ncbi.nlm.nih.gov/pubmed/35784827 http://dx.doi.org/10.1016/j.medcle.2021.07.021 |
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