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Artificial Metalloproteins: At the Interface between Biology and Chemistry
[Image: see text] Artificial metalloproteins (ArMs) have recently gained significant interest due to their potential to address issues in a broad scope of applications, including biocatalysis, biotechnology, protein assembly, and model chemistry. ArMs are assembled by the incorporation of a non-nati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241007/ https://www.ncbi.nlm.nih.gov/pubmed/35783165 http://dx.doi.org/10.1021/jacsau.2c00102 |
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author | Kerns, Spencer A. Biswas, Ankita Minnetian, Natalie M. Borovik, A. S. |
author_facet | Kerns, Spencer A. Biswas, Ankita Minnetian, Natalie M. Borovik, A. S. |
author_sort | Kerns, Spencer A. |
collection | PubMed |
description | [Image: see text] Artificial metalloproteins (ArMs) have recently gained significant interest due to their potential to address issues in a broad scope of applications, including biocatalysis, biotechnology, protein assembly, and model chemistry. ArMs are assembled by the incorporation of a non-native metallocofactor into a protein scaffold. This can be achieved by a number of methods that apply tools of chemical biology, computational de novo design, and synthetic chemistry. In this Perspective, we highlight select systems in the hope of demonstrating the breadth of ArM design strategies and applications and emphasize how these systems address problems that are otherwise difficult to do so with strictly biochemical or synthetic approaches. |
format | Online Article Text |
id | pubmed-9241007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-92410072022-06-30 Artificial Metalloproteins: At the Interface between Biology and Chemistry Kerns, Spencer A. Biswas, Ankita Minnetian, Natalie M. Borovik, A. S. JACS Au [Image: see text] Artificial metalloproteins (ArMs) have recently gained significant interest due to their potential to address issues in a broad scope of applications, including biocatalysis, biotechnology, protein assembly, and model chemistry. ArMs are assembled by the incorporation of a non-native metallocofactor into a protein scaffold. This can be achieved by a number of methods that apply tools of chemical biology, computational de novo design, and synthetic chemistry. In this Perspective, we highlight select systems in the hope of demonstrating the breadth of ArM design strategies and applications and emphasize how these systems address problems that are otherwise difficult to do so with strictly biochemical or synthetic approaches. American Chemical Society 2022-06-02 /pmc/articles/PMC9241007/ /pubmed/35783165 http://dx.doi.org/10.1021/jacsau.2c00102 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Kerns, Spencer A. Biswas, Ankita Minnetian, Natalie M. Borovik, A. S. Artificial Metalloproteins: At the Interface between Biology and Chemistry |
title | Artificial Metalloproteins: At the Interface between
Biology and Chemistry |
title_full | Artificial Metalloproteins: At the Interface between
Biology and Chemistry |
title_fullStr | Artificial Metalloproteins: At the Interface between
Biology and Chemistry |
title_full_unstemmed | Artificial Metalloproteins: At the Interface between
Biology and Chemistry |
title_short | Artificial Metalloproteins: At the Interface between
Biology and Chemistry |
title_sort | artificial metalloproteins: at the interface between
biology and chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241007/ https://www.ncbi.nlm.nih.gov/pubmed/35783165 http://dx.doi.org/10.1021/jacsau.2c00102 |
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