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Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds

The present study examined the phytochemical composition, antioxidant, antimicrobial properties, and molecular docking of different solvents extracts (methanol and water) of two medicinal plants, namely, Capparis spinosa L (CS) and Rumex nervosus (RN). Phytochemical analysis showed that total phenol...

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Autores principales: AlMousa, Lujain A., AlFaris, Nora A., Alshammari, Ghedeir M., ALTamimi, Jozaa Z., Alsyadi, Muneer M., Alagal, Reham I., Abdo Yahya, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241031/
https://www.ncbi.nlm.nih.gov/pubmed/35784613
http://dx.doi.org/10.1016/j.sjbs.2022.103346
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author AlMousa, Lujain A.
AlFaris, Nora A.
Alshammari, Ghedeir M.
ALTamimi, Jozaa Z.
Alsyadi, Muneer M.
Alagal, Reham I.
Abdo Yahya, Mohammed
author_facet AlMousa, Lujain A.
AlFaris, Nora A.
Alshammari, Ghedeir M.
ALTamimi, Jozaa Z.
Alsyadi, Muneer M.
Alagal, Reham I.
Abdo Yahya, Mohammed
author_sort AlMousa, Lujain A.
collection PubMed
description The present study examined the phytochemical composition, antioxidant, antimicrobial properties, and molecular docking of different solvents extracts (methanol and water) of two medicinal plants, namely, Capparis spinosa L (CS) and Rumex nervosus (RN). Phytochemical analysis showed that total phenol, flavonoids, alkaloids, and vitamin C were significantly (P ≤ 0.05) higher in the methanolic extract of both plants than in other solvents. However, tannin content was significantly (P ≤ 0.05) high in the water extract for both plants. Chloroform and acetone extracts were significantly lower in phytochemicals than other solvents, therefore excluded in this study. GC–MS analysis showed one dominant compound in CS (isopropyl isothiocyanate) and two in RN (pyrogallol and palmitic acid). The antioxidant methods applied (DPPH, ABTS, β-Carotene/linoleic acid assay, and reducing the power) showed that the methanolic extract of CS exerted higher activity in methanolic extract but lower than that of BHA standard. The methanolic extract of both plants inhibited the bacterial pathogens when a minimum inhibitory concentration (MIC) method was applied, compared to water extract with RN-methanolic extract had a lower inhibition concentration than CS-methanolic extract. The molecular interactions study revealed that the palmitic acid and pyrogallol interacted with the receptors' active site. This work concluded that CS and RN showed a remarkable antioxidant and antibacterial effect with the high antimicrobial activity of RN extract.
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spelling pubmed-92410312022-06-30 Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds AlMousa, Lujain A. AlFaris, Nora A. Alshammari, Ghedeir M. ALTamimi, Jozaa Z. Alsyadi, Muneer M. Alagal, Reham I. Abdo Yahya, Mohammed Saudi J Biol Sci Original Article The present study examined the phytochemical composition, antioxidant, antimicrobial properties, and molecular docking of different solvents extracts (methanol and water) of two medicinal plants, namely, Capparis spinosa L (CS) and Rumex nervosus (RN). Phytochemical analysis showed that total phenol, flavonoids, alkaloids, and vitamin C were significantly (P ≤ 0.05) higher in the methanolic extract of both plants than in other solvents. However, tannin content was significantly (P ≤ 0.05) high in the water extract for both plants. Chloroform and acetone extracts were significantly lower in phytochemicals than other solvents, therefore excluded in this study. GC–MS analysis showed one dominant compound in CS (isopropyl isothiocyanate) and two in RN (pyrogallol and palmitic acid). The antioxidant methods applied (DPPH, ABTS, β-Carotene/linoleic acid assay, and reducing the power) showed that the methanolic extract of CS exerted higher activity in methanolic extract but lower than that of BHA standard. The methanolic extract of both plants inhibited the bacterial pathogens when a minimum inhibitory concentration (MIC) method was applied, compared to water extract with RN-methanolic extract had a lower inhibition concentration than CS-methanolic extract. The molecular interactions study revealed that the palmitic acid and pyrogallol interacted with the receptors' active site. This work concluded that CS and RN showed a remarkable antioxidant and antibacterial effect with the high antimicrobial activity of RN extract. Elsevier 2022-08 2022-06-16 /pmc/articles/PMC9241031/ /pubmed/35784613 http://dx.doi.org/10.1016/j.sjbs.2022.103346 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
AlMousa, Lujain A.
AlFaris, Nora A.
Alshammari, Ghedeir M.
ALTamimi, Jozaa Z.
Alsyadi, Muneer M.
Alagal, Reham I.
Abdo Yahya, Mohammed
Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds
title Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds
title_full Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds
title_fullStr Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds
title_full_unstemmed Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds
title_short Antioxidant and antimicrobial potential of two extracts from Capparis spinosa L. and Rumex nervosus and molecular docking investigation of selected major compounds
title_sort antioxidant and antimicrobial potential of two extracts from capparis spinosa l. and rumex nervosus and molecular docking investigation of selected major compounds
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241031/
https://www.ncbi.nlm.nih.gov/pubmed/35784613
http://dx.doi.org/10.1016/j.sjbs.2022.103346
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