Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSα facilitates processing of oxidative DNA damage in human cells

Oxidative DNA damage contributes to aging and the pathogenesis of numerous human diseases including cancer. 8-hydroxyguanine (8-oxoG) is the major product of oxidative DNA lesions. Although OGG1-mediated base excision repair is the primary mechanism for 8-oxoG removal, DNA mismatch repair has also b...

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Detalles Bibliográficos
Autores principales: Guo, Sida, Fang, Jun, Xu, Weizhi, Ortega, Janice, Liu, Chang-Yi, Gu, Liya, Chang, Zhijie, Li, Guo-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241034/
https://www.ncbi.nlm.nih.gov/pubmed/35667440
http://dx.doi.org/10.1016/j.jbc.2022.102102

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