Massive hypertriglyceridemia associated with paclitaxel; a case report

This report describes a patient who developed massive hypertriglyceridemia (12,488 mg/dL or 141 mmol/L) during paclitaxel and carboplatin adjuvant chemotherapy for high grade serous fallopian tube carcinoma. Paclitaxel was thought to be the causative agent and she had normal triglyceride levels foll...

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Autores principales: Koneshamoorthy, Anojian, Hulse, Danielle, Yuen Chong, Chia, Krishnamurthy, Balasubramanian, Ananda, Sumitra, Hamblin, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241137/
https://www.ncbi.nlm.nih.gov/pubmed/35782104
http://dx.doi.org/10.1016/j.gore.2022.101030
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author Koneshamoorthy, Anojian
Hulse, Danielle
Yuen Chong, Chia
Krishnamurthy, Balasubramanian
Ananda, Sumitra
Hamblin, Peter S.
author_facet Koneshamoorthy, Anojian
Hulse, Danielle
Yuen Chong, Chia
Krishnamurthy, Balasubramanian
Ananda, Sumitra
Hamblin, Peter S.
author_sort Koneshamoorthy, Anojian
collection PubMed
description This report describes a patient who developed massive hypertriglyceridemia (12,488 mg/dL or 141 mmol/L) during paclitaxel and carboplatin adjuvant chemotherapy for high grade serous fallopian tube carcinoma. Paclitaxel was thought to be the causative agent and she had normal triglyceride levels following a change to carboplatin and gemcitabine. To our knowledge, this is the highest reported triglyceride level associated with paclitaxel. Measurement of serum lipids should be considered in individuals receiving taxane chemotherapy, especially in those with type 2 diabetes mellitus or a history of dyslipidemia.
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spelling pubmed-92411372022-06-30 Massive hypertriglyceridemia associated with paclitaxel; a case report Koneshamoorthy, Anojian Hulse, Danielle Yuen Chong, Chia Krishnamurthy, Balasubramanian Ananda, Sumitra Hamblin, Peter S. Gynecol Oncol Rep Case Report This report describes a patient who developed massive hypertriglyceridemia (12,488 mg/dL or 141 mmol/L) during paclitaxel and carboplatin adjuvant chemotherapy for high grade serous fallopian tube carcinoma. Paclitaxel was thought to be the causative agent and she had normal triglyceride levels following a change to carboplatin and gemcitabine. To our knowledge, this is the highest reported triglyceride level associated with paclitaxel. Measurement of serum lipids should be considered in individuals receiving taxane chemotherapy, especially in those with type 2 diabetes mellitus or a history of dyslipidemia. Elsevier 2022-06-25 /pmc/articles/PMC9241137/ /pubmed/35782104 http://dx.doi.org/10.1016/j.gore.2022.101030 Text en Crown Copyright © 2022 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Koneshamoorthy, Anojian
Hulse, Danielle
Yuen Chong, Chia
Krishnamurthy, Balasubramanian
Ananda, Sumitra
Hamblin, Peter S.
Massive hypertriglyceridemia associated with paclitaxel; a case report
title Massive hypertriglyceridemia associated with paclitaxel; a case report
title_full Massive hypertriglyceridemia associated with paclitaxel; a case report
title_fullStr Massive hypertriglyceridemia associated with paclitaxel; a case report
title_full_unstemmed Massive hypertriglyceridemia associated with paclitaxel; a case report
title_short Massive hypertriglyceridemia associated with paclitaxel; a case report
title_sort massive hypertriglyceridemia associated with paclitaxel; a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241137/
https://www.ncbi.nlm.nih.gov/pubmed/35782104
http://dx.doi.org/10.1016/j.gore.2022.101030
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