Cargando…

Aspiration of excess follicles before intrauterine insemination in high response cycles

PURPOSE: To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4–6 follicles ≥14 mm. METHODS: A retrospective case–control study with 1559 patients undergoing IUI (donor and husband's sperm), of whom 86 underw...

Descripción completa

Detalles Bibliográficos
Autores principales: Prieto, Begoña, Diaz‐Nuñez, Maria, Lainz, Lucia, Vendrell, Alberto, Rabanal, Aintzane, Iglesias, Maria, Jauregui, Teresa, Corcostegui, Beatriz, Matorras, Ana, Perez, Silvia, Matorras, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241166/
https://www.ncbi.nlm.nih.gov/pubmed/35781922
http://dx.doi.org/10.1002/rmb2.12470
_version_ 1784737737079783424
author Prieto, Begoña
Diaz‐Nuñez, Maria
Lainz, Lucia
Vendrell, Alberto
Rabanal, Aintzane
Iglesias, Maria
Jauregui, Teresa
Corcostegui, Beatriz
Matorras, Ana
Perez, Silvia
Matorras, Roberto
author_facet Prieto, Begoña
Diaz‐Nuñez, Maria
Lainz, Lucia
Vendrell, Alberto
Rabanal, Aintzane
Iglesias, Maria
Jauregui, Teresa
Corcostegui, Beatriz
Matorras, Ana
Perez, Silvia
Matorras, Roberto
author_sort Prieto, Begoña
collection PubMed
description PURPOSE: To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4–6 follicles ≥14 mm. METHODS: A retrospective case–control study with 1559 patients undergoing IUI (donor and husband's sperm), of whom 86 underwent EFABI. We studied also an historical series of 2213 patients before EFABI implementation. For 3.5 years, all women undergoing IUI developing 4–6 follicles ≥14 mm were offered EFABI on the day of hCG administration. Pregnancy rates (PRs), multiple PRs, and adverse effects were measured. RESULTS: EFABI was associated with a similar multiple PR (17.8% vs 17.5% in non‐EFABI cases), with no triplets in EFABI patients. Live birth rates were significantly higher in EFABI cycles in IUI overall (25.5% vs 15.2%). When considered separately, the performance of EFABI resulted in significantly increased live birth rates in IUI‐donor cycles (32.5% vs 18.5%), whereas the differences in IUI‐husband cycles (19.5% vs 12.9%) did not reach statistical significance. The PR was 21.2% during the EFABI implementation period and 19.4% in the pre‐EFABI period. CONCLUSIONS: EFABI in cycles in which 4–6 follicles reach ≥14 mm is a simple option that reduces cycle cancellation rates, results in higher PRs than cycles with 1–3 follicles, and lowers the risk of multiple pregnancy.
format Online
Article
Text
id pubmed-9241166
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-92411662022-07-01 Aspiration of excess follicles before intrauterine insemination in high response cycles Prieto, Begoña Diaz‐Nuñez, Maria Lainz, Lucia Vendrell, Alberto Rabanal, Aintzane Iglesias, Maria Jauregui, Teresa Corcostegui, Beatriz Matorras, Ana Perez, Silvia Matorras, Roberto Reprod Med Biol Original Articles PURPOSE: To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4–6 follicles ≥14 mm. METHODS: A retrospective case–control study with 1559 patients undergoing IUI (donor and husband's sperm), of whom 86 underwent EFABI. We studied also an historical series of 2213 patients before EFABI implementation. For 3.5 years, all women undergoing IUI developing 4–6 follicles ≥14 mm were offered EFABI on the day of hCG administration. Pregnancy rates (PRs), multiple PRs, and adverse effects were measured. RESULTS: EFABI was associated with a similar multiple PR (17.8% vs 17.5% in non‐EFABI cases), with no triplets in EFABI patients. Live birth rates were significantly higher in EFABI cycles in IUI overall (25.5% vs 15.2%). When considered separately, the performance of EFABI resulted in significantly increased live birth rates in IUI‐donor cycles (32.5% vs 18.5%), whereas the differences in IUI‐husband cycles (19.5% vs 12.9%) did not reach statistical significance. The PR was 21.2% during the EFABI implementation period and 19.4% in the pre‐EFABI period. CONCLUSIONS: EFABI in cycles in which 4–6 follicles reach ≥14 mm is a simple option that reduces cycle cancellation rates, results in higher PRs than cycles with 1–3 follicles, and lowers the risk of multiple pregnancy. John Wiley and Sons Inc. 2022-06-29 /pmc/articles/PMC9241166/ /pubmed/35781922 http://dx.doi.org/10.1002/rmb2.12470 Text en © 2022 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Prieto, Begoña
Diaz‐Nuñez, Maria
Lainz, Lucia
Vendrell, Alberto
Rabanal, Aintzane
Iglesias, Maria
Jauregui, Teresa
Corcostegui, Beatriz
Matorras, Ana
Perez, Silvia
Matorras, Roberto
Aspiration of excess follicles before intrauterine insemination in high response cycles
title Aspiration of excess follicles before intrauterine insemination in high response cycles
title_full Aspiration of excess follicles before intrauterine insemination in high response cycles
title_fullStr Aspiration of excess follicles before intrauterine insemination in high response cycles
title_full_unstemmed Aspiration of excess follicles before intrauterine insemination in high response cycles
title_short Aspiration of excess follicles before intrauterine insemination in high response cycles
title_sort aspiration of excess follicles before intrauterine insemination in high response cycles
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241166/
https://www.ncbi.nlm.nih.gov/pubmed/35781922
http://dx.doi.org/10.1002/rmb2.12470
work_keys_str_mv AT prietobegona aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT diaznunezmaria aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT lainzlucia aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT vendrellalberto aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT rabanalaintzane aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT iglesiasmaria aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT jaureguiteresa aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT corcosteguibeatriz aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT matorrasana aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT perezsilvia aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles
AT matorrasroberto aspirationofexcessfolliclesbeforeintrauterineinseminationinhighresponsecycles