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Aspiration of excess follicles before intrauterine insemination in high response cycles
PURPOSE: To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4–6 follicles ≥14 mm. METHODS: A retrospective case–control study with 1559 patients undergoing IUI (donor and husband's sperm), of whom 86 underw...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241166/ https://www.ncbi.nlm.nih.gov/pubmed/35781922 http://dx.doi.org/10.1002/rmb2.12470 |
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author | Prieto, Begoña Diaz‐Nuñez, Maria Lainz, Lucia Vendrell, Alberto Rabanal, Aintzane Iglesias, Maria Jauregui, Teresa Corcostegui, Beatriz Matorras, Ana Perez, Silvia Matorras, Roberto |
author_facet | Prieto, Begoña Diaz‐Nuñez, Maria Lainz, Lucia Vendrell, Alberto Rabanal, Aintzane Iglesias, Maria Jauregui, Teresa Corcostegui, Beatriz Matorras, Ana Perez, Silvia Matorras, Roberto |
author_sort | Prieto, Begoña |
collection | PubMed |
description | PURPOSE: To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4–6 follicles ≥14 mm. METHODS: A retrospective case–control study with 1559 patients undergoing IUI (donor and husband's sperm), of whom 86 underwent EFABI. We studied also an historical series of 2213 patients before EFABI implementation. For 3.5 years, all women undergoing IUI developing 4–6 follicles ≥14 mm were offered EFABI on the day of hCG administration. Pregnancy rates (PRs), multiple PRs, and adverse effects were measured. RESULTS: EFABI was associated with a similar multiple PR (17.8% vs 17.5% in non‐EFABI cases), with no triplets in EFABI patients. Live birth rates were significantly higher in EFABI cycles in IUI overall (25.5% vs 15.2%). When considered separately, the performance of EFABI resulted in significantly increased live birth rates in IUI‐donor cycles (32.5% vs 18.5%), whereas the differences in IUI‐husband cycles (19.5% vs 12.9%) did not reach statistical significance. The PR was 21.2% during the EFABI implementation period and 19.4% in the pre‐EFABI period. CONCLUSIONS: EFABI in cycles in which 4–6 follicles reach ≥14 mm is a simple option that reduces cycle cancellation rates, results in higher PRs than cycles with 1–3 follicles, and lowers the risk of multiple pregnancy. |
format | Online Article Text |
id | pubmed-9241166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92411662022-07-01 Aspiration of excess follicles before intrauterine insemination in high response cycles Prieto, Begoña Diaz‐Nuñez, Maria Lainz, Lucia Vendrell, Alberto Rabanal, Aintzane Iglesias, Maria Jauregui, Teresa Corcostegui, Beatriz Matorras, Ana Perez, Silvia Matorras, Roberto Reprod Med Biol Original Articles PURPOSE: To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4–6 follicles ≥14 mm. METHODS: A retrospective case–control study with 1559 patients undergoing IUI (donor and husband's sperm), of whom 86 underwent EFABI. We studied also an historical series of 2213 patients before EFABI implementation. For 3.5 years, all women undergoing IUI developing 4–6 follicles ≥14 mm were offered EFABI on the day of hCG administration. Pregnancy rates (PRs), multiple PRs, and adverse effects were measured. RESULTS: EFABI was associated with a similar multiple PR (17.8% vs 17.5% in non‐EFABI cases), with no triplets in EFABI patients. Live birth rates were significantly higher in EFABI cycles in IUI overall (25.5% vs 15.2%). When considered separately, the performance of EFABI resulted in significantly increased live birth rates in IUI‐donor cycles (32.5% vs 18.5%), whereas the differences in IUI‐husband cycles (19.5% vs 12.9%) did not reach statistical significance. The PR was 21.2% during the EFABI implementation period and 19.4% in the pre‐EFABI period. CONCLUSIONS: EFABI in cycles in which 4–6 follicles reach ≥14 mm is a simple option that reduces cycle cancellation rates, results in higher PRs than cycles with 1–3 follicles, and lowers the risk of multiple pregnancy. John Wiley and Sons Inc. 2022-06-29 /pmc/articles/PMC9241166/ /pubmed/35781922 http://dx.doi.org/10.1002/rmb2.12470 Text en © 2022 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Prieto, Begoña Diaz‐Nuñez, Maria Lainz, Lucia Vendrell, Alberto Rabanal, Aintzane Iglesias, Maria Jauregui, Teresa Corcostegui, Beatriz Matorras, Ana Perez, Silvia Matorras, Roberto Aspiration of excess follicles before intrauterine insemination in high response cycles |
title | Aspiration of excess follicles before intrauterine insemination in high response cycles |
title_full | Aspiration of excess follicles before intrauterine insemination in high response cycles |
title_fullStr | Aspiration of excess follicles before intrauterine insemination in high response cycles |
title_full_unstemmed | Aspiration of excess follicles before intrauterine insemination in high response cycles |
title_short | Aspiration of excess follicles before intrauterine insemination in high response cycles |
title_sort | aspiration of excess follicles before intrauterine insemination in high response cycles |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241166/ https://www.ncbi.nlm.nih.gov/pubmed/35781922 http://dx.doi.org/10.1002/rmb2.12470 |
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