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Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions

BACKGROUND: Coessentiality networks derived from CRISPR screens in cell lines provide a powerful framework for identifying functional modules in the cell and for inferring the roles of uncharacterized genes. However, these networks integrate signal across all underlying data and can mask strong inte...

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Detalles Bibliográficos
Autores principales:	Kim, Eiru, Novak, Lance C., Lin, Chenchu, Colic, Medina, Bertolet, Lori L., Gheorghe, Veronica, Bristow, Christopher A., Hart, Traver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241233/ https://www.ncbi.nlm.nih.gov/pubmed/35768873 http://dx.doi.org/10.1186/s13059-022-02712-z

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