Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

BACKGROUND: Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color. Leveraging existing large-scale genome-wide association studies (GWAS), polygenic risk scores (PRS) have shown promise to complement e...

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Detalles Bibliográficos
Autores principales: Ge, Tian, Irvin, Marguerite R., Patki, Amit, Srinivasasainagendra, Vinodh, Lin, Yen-Feng, Tiwari, Hemant K., Armstrong, Nicole D., Benoit, Barbara, Chen, Chia-Yen, Choi, Karmel W., Cimino, James J., Davis, Brittney H., Dikilitas, Ozan, Etheridge, Bethany, Feng, Yen-Chen Anne, Gainer, Vivian, Huang, Hailiang, Jarvik, Gail P., Kachulis, Christopher, Kenny, Eimear E., Khan, Atlas, Kiryluk, Krzysztof, Kottyan, Leah, Kullo, Iftikhar J., Lange, Christoph, Lennon, Niall, Leong, Aaron, Malolepsza, Edyta, Miles, Ayme D., Murphy, Shawn, Namjou, Bahram, Narayan, Renuka, O’Connor, Mark J., Pacheco, Jennifer A., Perez, Emma, Rasmussen-Torvik, Laura J., Rosenthal, Elisabeth A., Schaid, Daniel, Stamou, Maria, Udler, Miriam S., Wei, Wei-Qi, Weiss, Scott T., Ng, Maggie C. Y., Smoller, Jordan W., Lebo, Matthew S., Meigs, James B., Limdi, Nita A., Karlson, Elizabeth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241245/
https://www.ncbi.nlm.nih.gov/pubmed/35765100
http://dx.doi.org/10.1186/s13073-022-01074-2

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