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Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation
BACKGROUND: Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are still lacking. We aimed to evaluate the impacts of obesity and variability of...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241273/ https://www.ncbi.nlm.nih.gov/pubmed/35765047 http://dx.doi.org/10.1186/s12916-022-02413-1 |
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author | Zhao, Maoxiang Song, Lulu Zhao, Qianqian Chen, Yating Li, Bin Xie, Zhonghui Fu, Zihao Zhang, Nan Cheng, Xiaowei Li, Xiaoqian Wang, Miao Wu, Shouling Xue, Hao Li, Yang |
author_facet | Zhao, Maoxiang Song, Lulu Zhao, Qianqian Chen, Yating Li, Bin Xie, Zhonghui Fu, Zihao Zhang, Nan Cheng, Xiaowei Li, Xiaoqian Wang, Miao Wu, Shouling Xue, Hao Li, Yang |
author_sort | Zhao, Maoxiang |
collection | PubMed |
description | BACKGROUND: Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are still lacking. We aimed to evaluate the impacts of obesity and variability of body mass index (BMI) and waist circumference (WC) on the risk of atrial fibrillation (AF) in a large Chinese cohort study. METHODS: A total of 44,135 participants of the Kailuan Study who were free of cancer and cardiovascular disease and underwent three consecutive surveys from 2006 to 2010 were followed for incident AF until 2020. Average BMI and WC over time and variability were calculated. Cox proportional hazards regression models were used to assess hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of obesity and variability in BMI and WC with AF risk. RESULTS: During a mean follow-up of 9.68 years, there were 410 cases of incident AF. In multivariable-adjusted models, compared with normal BMI/WC, individuals with general obesity and abdominal obesity had increased risk of AF, with corresponding HRs of 1.73 (95% CI: 1.31–2.30) and 1.38 (95% CI: 1.11–1.60), respectively. The short-term elevation in AF risk persisted for the obese even after adjustment for updated biologic intermediaries and weight. Variability in BMI and WC were not associated with the risk of AF. The restricted cubic spline models indicated significant linear relationships between levels of WC and BMI and risk of AF. CONCLUSIONS: Elevated levels of BMI and WC were associated with an increased risk of AF, whereas variability in BMI and WC were not. Therefore, achieving optimal levels of BMI and WC could be valuable in AF prevention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02413-1. |
format | Online Article Text |
id | pubmed-9241273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92412732022-06-30 Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation Zhao, Maoxiang Song, Lulu Zhao, Qianqian Chen, Yating Li, Bin Xie, Zhonghui Fu, Zihao Zhang, Nan Cheng, Xiaowei Li, Xiaoqian Wang, Miao Wu, Shouling Xue, Hao Li, Yang BMC Med Research Article BACKGROUND: Although obesity has been associated with risk of atrial fibrillation (AF), the associations of variability of obesity measures with AF risk are uncertain, and longitudinal studies among Chinese population are still lacking. We aimed to evaluate the impacts of obesity and variability of body mass index (BMI) and waist circumference (WC) on the risk of atrial fibrillation (AF) in a large Chinese cohort study. METHODS: A total of 44,135 participants of the Kailuan Study who were free of cancer and cardiovascular disease and underwent three consecutive surveys from 2006 to 2010 were followed for incident AF until 2020. Average BMI and WC over time and variability were calculated. Cox proportional hazards regression models were used to assess hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of obesity and variability in BMI and WC with AF risk. RESULTS: During a mean follow-up of 9.68 years, there were 410 cases of incident AF. In multivariable-adjusted models, compared with normal BMI/WC, individuals with general obesity and abdominal obesity had increased risk of AF, with corresponding HRs of 1.73 (95% CI: 1.31–2.30) and 1.38 (95% CI: 1.11–1.60), respectively. The short-term elevation in AF risk persisted for the obese even after adjustment for updated biologic intermediaries and weight. Variability in BMI and WC were not associated with the risk of AF. The restricted cubic spline models indicated significant linear relationships between levels of WC and BMI and risk of AF. CONCLUSIONS: Elevated levels of BMI and WC were associated with an increased risk of AF, whereas variability in BMI and WC were not. Therefore, achieving optimal levels of BMI and WC could be valuable in AF prevention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02413-1. BioMed Central 2022-06-29 /pmc/articles/PMC9241273/ /pubmed/35765047 http://dx.doi.org/10.1186/s12916-022-02413-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Zhao, Maoxiang Song, Lulu Zhao, Qianqian Chen, Yating Li, Bin Xie, Zhonghui Fu, Zihao Zhang, Nan Cheng, Xiaowei Li, Xiaoqian Wang, Miao Wu, Shouling Xue, Hao Li, Yang Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation |
title | Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation |
title_full | Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation |
title_fullStr | Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation |
title_full_unstemmed | Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation |
title_short | Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation |
title_sort | elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241273/ https://www.ncbi.nlm.nih.gov/pubmed/35765047 http://dx.doi.org/10.1186/s12916-022-02413-1 |
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