Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition

BACKGROUND: The apolipoprotein E (APOE) ε4 allele confers the strongest risk for late-onset Alzheimer’s disease (AD) besides age itself, but the mechanisms underlying this risk are debated. One hypothesis supported by evidence from multiple labs is that apoE4 binds to the amyloid-β (Aβ) peptide and...

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Detalles Bibliográficos
Autores principales: Johnson, Noah R., Wang, Athena C.-J., Coughlan, Christina, Sillau, Stefan, Lucero, Esteban, Viltz, Lisa, Markham, Neil, Allen, Cody, Dhanasekaran, A. Ranjitha, Chial, Heidi J., Potter, Huntington
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241285/
https://www.ncbi.nlm.nih.gov/pubmed/35768831
http://dx.doi.org/10.1186/s13195-022-01020-9

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