Cargando…

Ceritinib is a novel triple negative breast cancer therapeutic agent

BACKGROUND: Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype. Androgen receptor (AR) has been detected in 12–55% of TNBCs. AR stimulates breas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Shengli, Yousefi, Hassan, Savage, Isabella Van, Okpechi, Samuel C., Wright, Maryl K., Matossian, Margarite D., Collins-Burow, Bridgette M., Burow, Matthew E., Alahari, Suresh K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241294/ https://www.ncbi.nlm.nih.gov/pubmed/35768871 http://dx.doi.org/10.1186/s12943-022-01601-0

Ejemplares similares

Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy
por: Dong, Shengli, et al.
Publicado: (2023)

Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment
por: Nguyen, Khoa, et al.
Publicado: (2021)

Liver Kinase B1 Regulates Remodeling of the Tumor Microenvironment in Triple-Negative Breast Cancer
por: King, Connor T., et al.
Publicado: (2022)

436 Examining the Role of Obesity and Leptin Signaling in Triple Negative Breast Cancer
por: Brock, Courtney, et al.
Publicado: (2022)

Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer
por: Matossian, Margarite D., et al.
Publicado: (2020)

Panobinostat suppresses the mesenchymal phenotype in a novel claudin-low triple negative patient-derived breast cancer model
por: Matossian, Margarite D., et al.
Publicado: (2018)

Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes
por: Matossian, Margarite D., et al.
Publicado: (2017)

Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer
por: Matossian, Margarite D., et al.
Publicado: (2021)

Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models
por: Sabol, Rachel A., et al.
Publicado: (2019)

56371 The Signaling Axis of Tumor Suppressor LKB1 in Triple Negative Breast Cancer
por: Nguyen, Khoa, et al.
Publicado: (2021)

ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer
por: Hoang, Van T., et al.
Publicado: (2020)

Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer
por: Hossain, Fokhrul, et al.
Publicado: (2023)

GD2+ cancer stem cells in triple-negative breast cancer: mechanisms of resistance to breast cancer therapies
por: Nguyen, Khoa, et al.
Publicado: (2022)

Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways
por: Hossain, Fokhrul, et al.
Publicado: (2018)

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model
por: Matossian, Margarite D., et al.
Publicado: (2019)

Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat
por: Tate, Chandra R, et al.
Publicado: (2012)

Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action()
por: Yousefi, Hassan, et al.
Publicado: (2021)

Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells
por: Matossian, Margarite D., et al.
Publicado: (2021)

Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue
por: Gurrala, Rakesh, et al.
Publicado: (2021)

Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH(Δ5-6) Knockout Mouse Model
por: Nguyen, Tina H., et al.
Publicado: (2022)

Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer
por: Rhodes, Lyndsay V., et al.
Publicado: (2015)

A Role for Adipocytes and Adipose Stem Cells in the Breast Tumor Microenvironment and Regenerative Medicine
por: Brock, Courtney K., et al.
Publicado: (2021)

Obesity-Altered Adipose Stem Cells Promote ER(+) Breast Cancer Metastasis through Estrogen Independent Pathways
por: Sabol, Rachel A., et al.
Publicado: (2019)

Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor
por: Chang, Tiffany C., et al.
Publicado: (2020)

Correction: Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor
por: Chang, Tiffany C., et al.
Publicado: (2021)

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling
por: Bhatt, Akshita B., et al.
Publicado: (2021)

Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1
por: Rhodes, L V, et al.
Publicado: (2015)

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer
por: Bhatt, Akshita B., et al.
Publicado: (2021)

Induction of HOXA9 expression in three-dimensional organotypic culture of the Claudin-low breast cancer cells
por: Li, Miao, et al.
Publicado: (2016)

235 Analysiss of TNBC Cell Lines Cultured a Novel Translational Breast Cancer Microphysiological System (BC-MPS)
por: Hebert, Katherine L., et al.
Publicado: (2022)

miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling
por: Martin, Elizabeth C., et al.
Publicado: (2014)

Insulin-Like Growth Factor-1 Signaling Regulates miRNA Expression in MCF-7 Breast Cancer Cell Line
por: Martin, Elizabeth C., et al.
Publicado: (2012)

NR4A Family Genes: A Review of Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer
por: Yousefi, Hassan, et al.
Publicado: (2022)

microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity
por: Martin, Elizabeth C, et al.
Publicado: (2014)

Novel Diphenylamine Analogs Induce Mesenchymal to Epithelial Transition in Triple Negative Breast Cancer
por: Bhatt, Akshita B., et al.
Publicado: (2019)

NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types
por: Nguyen, Khoa, et al.
Publicado: (2023)

Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration
por: Zhou, Changhua, et al.
Publicado: (2012)

Safety and Activity of the Combination of Ceritinib and Dasatinib in Osteosarcoma
por: Beck, Olaf, et al.
Publicado: (2020)

Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transition
por: ANTOON, JAMES W., et al.
Publicado: (2013)

Local Use of Chlorate of Potassa in Open Carcinoma
por: Burow,
Publicado: (1873)

Cannot write session to /tmp/vufind_sessions/sess_skb1ser9vdgj6f8cfkm8jopmeo