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Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a geographically and racially variable disease that has a high incidence in Southeast China. According to previous studies on tumor immunity, we compared multiple clinical parameters and blood indexes with outcomes regarding to Epstein-Barr virus (EBV) s...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241295/ https://www.ncbi.nlm.nih.gov/pubmed/35768843 http://dx.doi.org/10.1186/s12885-022-09438-y |
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author | Zhu, Jing Fang, Ruhua Pan, Zhiwen Qian, Xu |
author_facet | Zhu, Jing Fang, Ruhua Pan, Zhiwen Qian, Xu |
author_sort | Zhu, Jing |
collection | PubMed |
description | BACKGROUND: Nasopharyngeal carcinoma (NPC) is a geographically and racially variable disease that has a high incidence in Southeast China. According to previous studies on tumor immunity, we compared multiple clinical parameters and blood indexes with outcomes regarding to Epstein-Barr virus (EBV) status in NPC patients. METHODS: According to the EBV load at diagnosis, 220 NPC patients who received concurrent chemoradiotherapy (CRT) were divided into two groups: EBV DNA ≥ 1500 copies/mL and EBV DNA < 1500 copies/mL, respectively. We compared clinical parameters with peripheral blood mononuclear cells, lymphocyte subsets and biochemical indexes. We also analyzed distant metastases and the overall survival rate regarding to these characteristics. RESULTS: In most cases, the two groups showed the same trends. Most blood indexes were decreased during CRT and the decrease of the absolute count was more significant than the percentage. Patients with younger age showed the higher CD3+ and CD3 + CD8+ percentages. Patients whose EBV DNA ≥ 1500 copies/mL showed a higher N classification than those with EBV DNA < 1500 copies/mL at first diagnosis. Within patients with EBV DNA ≥ 1500 copies/mL, a higher CD3 + CD8+ percentage or lower CD3-CD56+ percentage had better OS rates, and the CD3 + CD8+ percentage was an independent prognostic factor by multivariate survival analyses. CONCLUSIONS: CRT caused an overall decrease of blood cells in NPC patients. Among all the blood indexes, the CD3 + CD8+ percentage showed a correlation with age and was an independent prognostic factor in patients with EBV DNA ≥ 1500 copies/mL at first diagnosis, which is worthy for further large cohort study. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09438-y. |
format | Online Article Text |
id | pubmed-9241295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92412952022-06-30 Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma Zhu, Jing Fang, Ruhua Pan, Zhiwen Qian, Xu BMC Cancer Research BACKGROUND: Nasopharyngeal carcinoma (NPC) is a geographically and racially variable disease that has a high incidence in Southeast China. According to previous studies on tumor immunity, we compared multiple clinical parameters and blood indexes with outcomes regarding to Epstein-Barr virus (EBV) status in NPC patients. METHODS: According to the EBV load at diagnosis, 220 NPC patients who received concurrent chemoradiotherapy (CRT) were divided into two groups: EBV DNA ≥ 1500 copies/mL and EBV DNA < 1500 copies/mL, respectively. We compared clinical parameters with peripheral blood mononuclear cells, lymphocyte subsets and biochemical indexes. We also analyzed distant metastases and the overall survival rate regarding to these characteristics. RESULTS: In most cases, the two groups showed the same trends. Most blood indexes were decreased during CRT and the decrease of the absolute count was more significant than the percentage. Patients with younger age showed the higher CD3+ and CD3 + CD8+ percentages. Patients whose EBV DNA ≥ 1500 copies/mL showed a higher N classification than those with EBV DNA < 1500 copies/mL at first diagnosis. Within patients with EBV DNA ≥ 1500 copies/mL, a higher CD3 + CD8+ percentage or lower CD3-CD56+ percentage had better OS rates, and the CD3 + CD8+ percentage was an independent prognostic factor by multivariate survival analyses. CONCLUSIONS: CRT caused an overall decrease of blood cells in NPC patients. Among all the blood indexes, the CD3 + CD8+ percentage showed a correlation with age and was an independent prognostic factor in patients with EBV DNA ≥ 1500 copies/mL at first diagnosis, which is worthy for further large cohort study. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-022-09438-y. BioMed Central 2022-06-29 /pmc/articles/PMC9241295/ /pubmed/35768843 http://dx.doi.org/10.1186/s12885-022-09438-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhu, Jing Fang, Ruhua Pan, Zhiwen Qian, Xu Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma |
title | Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma |
title_full | Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma |
title_fullStr | Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma |
title_full_unstemmed | Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma |
title_short | Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma |
title_sort | circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241295/ https://www.ncbi.nlm.nih.gov/pubmed/35768843 http://dx.doi.org/10.1186/s12885-022-09438-y |
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