Directed mutational scanning reveals a balance between acidic and hydrophobic residues in strong human activation domains

Acidic activation domains are intrinsically disordered regions of the transcription factors that bind coactivators. The intrinsic disorder and low evolutionary conservation of activation domains have made it difficult to identify the sequence features that control activity. To address this problem,...

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Detalles Bibliográficos
Autores principales: Staller, Max V., Ramirez, Eddie, Kotha, Sanjana R., Holehouse, Alex S., Pappu, Rohit V., Cohen, Barak A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241528/
https://www.ncbi.nlm.nih.gov/pubmed/35120642
http://dx.doi.org/10.1016/j.cels.2022.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241528/
https://www.ncbi.nlm.nih.gov/pubmed/35120642
http://dx.doi.org/10.1016/j.cels.2022.01.002

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