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Directed mutational scanning reveals a balance between acidic and hydrophobic residues in strong human activation domains
Acidic activation domains are intrinsically disordered regions of the transcription factors that bind coactivators. The intrinsic disorder and low evolutionary conservation of activation domains have made it difficult to identify the sequence features that control activity. To address this problem,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241528/ https://www.ncbi.nlm.nih.gov/pubmed/35120642 http://dx.doi.org/10.1016/j.cels.2022.01.002 |