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Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence

In flavivirus, the furin-mediated cleavage of prM is mandatory to produce infectious particles, and the immature particles containing uncleaved prM cannot undergo membrane fusion and release to the extracellular environment. However, the detailed relationship between viral replication or pathogenici...

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Detalles Bibliográficos
Autores principales:	Xiong, Junyao, Yan, Mengxue, Zhu, Shuo, Zheng, Bohan, Wei, Ning, Yang, Lingen, Si, Youhui, Cao, Shengbo, Ye, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9241796/ https://www.ncbi.nlm.nih.gov/pubmed/35695552 http://dx.doi.org/10.1128/spectrum.01417-22

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