Cargando…

The AAV-PCSK9 murine model of atherosclerosis and metabolic dysfunction

AIMS: Mouse models with genetic modifications are required to investigate atherogenesis and associated metabolic syndrome. Adeno-associated virus-8 (AAV8)-mediated overexpression of PCSK9 (AAV8-PCSK9) induces hyperlipidaemia and promotes atherosclerosis in C57BL/6 mice. We aimed to assess whether AA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keeter, William Coles, Carter, Nigeste M, Nadler, Jerry L, Galkina, Elena V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242032/ https://www.ncbi.nlm.nih.gov/pubmed/35919346 http://dx.doi.org/10.1093/ehjopen/oeac028

Ejemplares similares

Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr(−/−) mice.
por: Keeter, W. Coles, et al.
Publicado: (2023)

Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr(−/−) mice
por: Keeter, W. Coles, et al.
Publicado: (2023)

AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9(DY) atherosclerosis mouse model
por: Achner, Leonie, et al.
Publicado: (2022)

PCSK9 and Atherosclerosis - Lipids and Beyond
por: Shapiro, Michael D., et al.
Publicado: (2017)

An Update on the Role of PCSK9 in Atherosclerosis
por: Yurtseven, Ece, et al.
Publicado: (2020)

PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction
por: Sun, Hua, et al.
Publicado: (2018)

Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation
por: Kumar, Sandeep, et al.
Publicado: (2017)

Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond
por: Seidah, Nabil G., et al.
Publicado: (2022)

Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis
por: Cao, DuoYao, et al.
Publicado: (2023)

Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet
por: Zhang, Xiao-lei, et al.
Publicado: (2023)

New developments in atherosclerosis: clinical potential of PCSK9 inhibition
por: Giunzioni, Ilaria, et al.
Publicado: (2015)

PCSK9/LDLR System and Rheumatoid Arthritis-Related Atherosclerosis
por: Arida, Aikaterini, et al.
Publicado: (2021)

Effects of PCSK9 Targeting: Alleviating Oxidation, Inflammation, and Atherosclerosis
por: Punch, Emily, et al.
Publicado: (2022)

Association of PCSK9 plasma levels with metabolic patterns and coronary atherosclerosis in patients with stable angina
por: Caselli, Chiara, et al.
Publicado: (2019)

STAT4 is expressed in neutrophils and promotes antimicrobial immunity
por: Mehrpouya-Bahrami, Pegah, et al.
Publicado: (2021)

PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation
por: Luquero, Aureli, et al.
Publicado: (2021)

Interactions between PCSK9 and NLRP3 inflammasome signaling in atherosclerosis
por: Wang, Yanan, et al.
Publicado: (2023)

The Concentration of PCSK9-Lp(a) Complexes and the Level of Blood Monocytes in Males with Coronary Atherosclerosis
por: Filatova, Anastasiia Yu., et al.
Publicado: (2023)

Relationship between Circulating PCSK9 and Markers of Subclinical Atherosclerosis—The IMPROVE Study
por: Coggi, Daniela, et al.
Publicado: (2021)

In vivo PCSK9 gene editing using an all-in-one self-cleavage AAV-CRISPR system
por: Li, Qian, et al.
Publicado: (2021)

Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis
por: Momtazi-Borojeni, Amir Abbas, et al.
Publicado: (2019)

PCSK9 immunization using nanoliposomes: preventive efficacy against hypercholesterolemia and atherosclerosis
por: Momtazi-Borojeni, Amir Abbas, et al.
Publicado: (2021)

PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system
por: Lee, Jounghyun H., et al.
Publicado: (2023)

Acute TSH stimulation in vivo does not alter serum PCSK9 levels
por: Gagnon, AnneMarie, et al.
Publicado: (2014)

PCSK9 and triglyceride-rich lipoprotein metabolism
por: Druce, Irena, et al.
Publicado: (2015)

PCSK9 targets important for lipid metabolism
por: Schulz, Rainer, et al.
Publicado: (2017)

Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX-1 in apoE(-/-) mice
por: Yan, Li, et al.
Publicado: (2021)

PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis
por: Kong, Ni, et al.
Publicado: (2022)

Immune Response at the Crossroads of Atherosclerosis and Alzheimer's Disease
por: Stahr, Natalie, et al.
Publicado: (2022)

Exploring the Link between Plasma Levels of PCSK9, Immune Dysregulation and Atherosclerosis in Patients with Primary Sjögren’s Syndrome
por: Bianconi, Vanessa, et al.
Publicado: (2023)

Research progress on alternative non-classical mechanisms of PCSK9 in atherosclerosis in patients with and without diabetes
por: Tang, Ying, et al.
Publicado: (2020)

Role of PCSK9 in Homocysteine-Accelerated Lipid Accumulation in Macrophages and Atherosclerosis in ApoE(−/−) Mice
por: Jin, Ping, et al.
Publicado: (2021)

Variants of PCSK9 Gene Are Associated with Subclinical Atherosclerosis and Cardiometabolic Parameters in Mexicans. The GEA Project
por: Zamarrón-Licona, Erasmo, et al.
Publicado: (2021)

Retraction Note: Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis
por: Momtazi-Borojeni, Amir Abbas, et al.
Publicado: (2023)

AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria
por: Richards, Daelyn Y., et al.
Publicado: (2019)

FOURIER & PCSK9 RNAi: Towards enhancing durability and efficacy of PCSK9 inhibitors
por: Hassan, Mohamed
Publicado: (2017)

The PCSK9 revolution and the potential of PCSK9-based therapies to reduce LDL-cholesterol
por: Seidah, Nabil G.
Publicado: (2017)

Functional Role of B Cells in Atherosclerosis
por: Ma, Shelby D., et al.
Publicado: (2021)

Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol
por: Ioannou, George N., et al.
Publicado: (2021)

PCSK9 in Myocardial Infarction and Cardioprotection: Importance of Lipid Metabolism and Inflammation
por: Andreadou, Ioanna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1jq290i75t4ceddjf0p3hjhe9c