Highly protective antimalarial antibodies via precision library generation and yeast display screening

The monoclonal antibody CIS43 targets the Plasmodium falciparum circumsporozoite protein (PfCSP) and prevents malaria infection in humans for up to 9 mo following a single intravenous administration. To enhance the potency and clinical utility of CIS43, we used iterative site-saturation mutagenesis...

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Detalles Bibliográficos
Autores principales: Banach, Bailey B., Tripathi, Prabhanshu, Da Silva Pereira, Lais, Gorman, Jason, Nguyen, Thuy Duong, Dillon, Marlon, Fahad, Ahmed S., Kiyuka, Patience K., Madan, Bharat, Wolfe, Jacy R., Bonilla, Brian, Flynn, Barbara, Francica, Joseph R., Hurlburt, Nicholas K., Kisalu, Neville K., Liu, Tracy, Ou, Li, Rawi, Reda, Schön, Arne, Shen, Chen-Hsiang, Teng, I-Ting, Zhang, Baoshan, Pancera, Marie, Idris, Azza H., Seder, Robert A., Kwong, Peter D., DeKosky, Brandon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Technical Advances and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242090/
https://www.ncbi.nlm.nih.gov/pubmed/35736810
http://dx.doi.org/10.1084/jem.20220323

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