Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2

Dexamethasone may reduce mortality in COVID-19 patients. Whether dexamethasone or endogenous glucocorticoids, such as cortisol, biochemically interact with SARS-CoV-2 spike 1 protein (S1), or its cellular receptor ACE2, is unknown. Using molecular dynamics (MD) simulations and binding energy calcula...

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Detalles Bibliográficos
Autores principales: Sarker, Hassan, Panigrahi, Rashmi, Hardy, Eugenio, Glover, J. N. Mark, Elahi, Shokrollah, Fernandez-Patron, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242398/
https://www.ncbi.nlm.nih.gov/pubmed/35784352
http://dx.doi.org/10.3389/fimmu.2022.906687

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