Cargando…
The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China
PURPOSE: The effects of statins on renal outcomes have already been studied in patients with chronic kidney disease (CKD); however, data on the general population are limited. We evaluated the association between statin use and risk of CKD in community-dwelling older people in Shanghai, China. PATIE...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242432/ https://www.ncbi.nlm.nih.gov/pubmed/35782995 http://dx.doi.org/10.2147/CLEP.S360395 |
_version_ | 1784738055907704832 |
---|---|
author | Zhao, Miaomiao Ren, Longbing Zhou, Zhitong Wang, Tao Li, Jue |
author_facet | Zhao, Miaomiao Ren, Longbing Zhou, Zhitong Wang, Tao Li, Jue |
author_sort | Zhao, Miaomiao |
collection | PubMed |
description | PURPOSE: The effects of statins on renal outcomes have already been studied in patients with chronic kidney disease (CKD); however, data on the general population are limited. We evaluated the association between statin use and risk of CKD in community-dwelling older people in Shanghai, China. PATIENTS AND METHODS: This registry-based cohort study was conducted in four communities in four districts in Shanghai. Participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2) in 2016 were eligible for the study, and new-onset CKD in 2017, 2018, and 2019 was recorded. Poisson generalized linear models were conducted to examine the relationships among statin therapy, dyslipidemia, and CKD; linear mixed-effects models were conducted to examine the relationships between statin therapy and changes in eGFR. All analyses were performed with both conventional adjustment and propensity score-matching methods. RESULTS: Of the study cohort of 2455 participants (41.1% men; average age, 68.06 years), 624 (25.4%) were treated with stains. Two propensity score-matched cohorts of 604 participants each were analyzed (statin users and nonusers). Statin use was significantly associated with a decreased risk of new-onset CKD with hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.73 (0.59 to 0.91) (p<0.01) in the unmatched cohort and 0.75 (0.59 to 0.97) (p=0.02) in the matched cohort. There were significant differences in the eGFR decline between statin users and nonusers from baseline to 3 years in the unmatched and matched cohorts (both p<0.05). In addition, both statin users and nonusers with dyslipidemia experienced more new-onset CKD (both p<0.05). CONCLUSION: Statin use was significantly associated with a decreased risk of new-onset CKD and a slower decline in eGFR in community-dwelling older people. Meanwhile, dyslipidemia was a risk factor for CKD progression among both statin users and nonusers. |
format | Online Article Text |
id | pubmed-9242432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-92424322022-06-30 The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China Zhao, Miaomiao Ren, Longbing Zhou, Zhitong Wang, Tao Li, Jue Clin Epidemiol Original Research PURPOSE: The effects of statins on renal outcomes have already been studied in patients with chronic kidney disease (CKD); however, data on the general population are limited. We evaluated the association between statin use and risk of CKD in community-dwelling older people in Shanghai, China. PATIENTS AND METHODS: This registry-based cohort study was conducted in four communities in four districts in Shanghai. Participants with an estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2) in 2016 were eligible for the study, and new-onset CKD in 2017, 2018, and 2019 was recorded. Poisson generalized linear models were conducted to examine the relationships among statin therapy, dyslipidemia, and CKD; linear mixed-effects models were conducted to examine the relationships between statin therapy and changes in eGFR. All analyses were performed with both conventional adjustment and propensity score-matching methods. RESULTS: Of the study cohort of 2455 participants (41.1% men; average age, 68.06 years), 624 (25.4%) were treated with stains. Two propensity score-matched cohorts of 604 participants each were analyzed (statin users and nonusers). Statin use was significantly associated with a decreased risk of new-onset CKD with hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.73 (0.59 to 0.91) (p<0.01) in the unmatched cohort and 0.75 (0.59 to 0.97) (p=0.02) in the matched cohort. There were significant differences in the eGFR decline between statin users and nonusers from baseline to 3 years in the unmatched and matched cohorts (both p<0.05). In addition, both statin users and nonusers with dyslipidemia experienced more new-onset CKD (both p<0.05). CONCLUSION: Statin use was significantly associated with a decreased risk of new-onset CKD and a slower decline in eGFR in community-dwelling older people. Meanwhile, dyslipidemia was a risk factor for CKD progression among both statin users and nonusers. Dove 2022-06-25 /pmc/articles/PMC9242432/ /pubmed/35782995 http://dx.doi.org/10.2147/CLEP.S360395 Text en © 2022 Zhao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Zhao, Miaomiao Ren, Longbing Zhou, Zhitong Wang, Tao Li, Jue The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China |
title | The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China |
title_full | The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China |
title_fullStr | The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China |
title_full_unstemmed | The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China |
title_short | The Association Between Statin Use and Risk of Chronic Kidney Disease in Community-Dwelling Older People in Shanghai, China |
title_sort | association between statin use and risk of chronic kidney disease in community-dwelling older people in shanghai, china |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242432/ https://www.ncbi.nlm.nih.gov/pubmed/35782995 http://dx.doi.org/10.2147/CLEP.S360395 |
work_keys_str_mv | AT zhaomiaomiao theassociationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT renlongbing theassociationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT zhouzhitong theassociationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT wangtao theassociationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT lijue theassociationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT zhaomiaomiao associationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT renlongbing associationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT zhouzhitong associationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT wangtao associationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina AT lijue associationbetweenstatinuseandriskofchronickidneydiseaseincommunitydwellingolderpeopleinshanghaichina |