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Glucose level detection using millimetre-wave metamaterial-inspired resonator

Millimetre-wave frequencies are promising for sensitive detection of glucose levels in the blood, where the temperature effect is insignificant. All these features provide the feasibility of continuous, portable, and accurate monitoring of glucose levels. This paper presents a metamaterial-inspired...

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Autores principales: Qureshi, Suhail Asghar, Abidin, Zuhairiah Zainal, Elamin, N. I. M., A. Majid, Huda, Ashyap, Adel Y. I., Nebhen, Jamel, Kamarudin, M. R., See, Chan Hwang, Abd-Alhameed, R. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242449/
https://www.ncbi.nlm.nih.gov/pubmed/35767587
http://dx.doi.org/10.1371/journal.pone.0269060
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author Qureshi, Suhail Asghar
Abidin, Zuhairiah Zainal
Elamin, N. I. M.
A. Majid, Huda
Ashyap, Adel Y. I.
Nebhen, Jamel
Kamarudin, M. R.
See, Chan Hwang
Abd-Alhameed, R. A.
author_facet Qureshi, Suhail Asghar
Abidin, Zuhairiah Zainal
Elamin, N. I. M.
A. Majid, Huda
Ashyap, Adel Y. I.
Nebhen, Jamel
Kamarudin, M. R.
See, Chan Hwang
Abd-Alhameed, R. A.
author_sort Qureshi, Suhail Asghar
collection PubMed
description Millimetre-wave frequencies are promising for sensitive detection of glucose levels in the blood, where the temperature effect is insignificant. All these features provide the feasibility of continuous, portable, and accurate monitoring of glucose levels. This paper presents a metamaterial-inspired resonator comprising five split-rings to detect glucose levels at 24.9 GHz. The plexiglass case containing blood is modelled on the sensor’s surface and the structure is simulated for the glucose levels in blood from 50 mg/dl to 120 mg/dl. The novelty of the sensor is demonstrated by the capability to sense the normal glucose levels at millimetre-wave frequencies. The dielectric characteristics of the blood are modelled by using the Debye parameters. The proposed design can detect small changes in the dielectric properties of blood caused by varying glucose levels. The variation in the transmission coefficient for each glucose level tested in this study is determined by the quality factor and resonant frequency. The sensor presented can detect the change in the quality factor of transmission response up to 2.71/mg/dl. The sensor’s performance has also been tested to detect diabetic hyperosmolar syndrome. The sensor showed a linear shift in resonant frequency with the change in glucose levels, and an R(2) of 0.9976 was obtained by applying regression analysis. Thus, the sensor can be used to monitor glucose in a normal range as well as at extreme levels.
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spelling pubmed-92424492022-06-30 Glucose level detection using millimetre-wave metamaterial-inspired resonator Qureshi, Suhail Asghar Abidin, Zuhairiah Zainal Elamin, N. I. M. A. Majid, Huda Ashyap, Adel Y. I. Nebhen, Jamel Kamarudin, M. R. See, Chan Hwang Abd-Alhameed, R. A. PLoS One Research Article Millimetre-wave frequencies are promising for sensitive detection of glucose levels in the blood, where the temperature effect is insignificant. All these features provide the feasibility of continuous, portable, and accurate monitoring of glucose levels. This paper presents a metamaterial-inspired resonator comprising five split-rings to detect glucose levels at 24.9 GHz. The plexiglass case containing blood is modelled on the sensor’s surface and the structure is simulated for the glucose levels in blood from 50 mg/dl to 120 mg/dl. The novelty of the sensor is demonstrated by the capability to sense the normal glucose levels at millimetre-wave frequencies. The dielectric characteristics of the blood are modelled by using the Debye parameters. The proposed design can detect small changes in the dielectric properties of blood caused by varying glucose levels. The variation in the transmission coefficient for each glucose level tested in this study is determined by the quality factor and resonant frequency. The sensor presented can detect the change in the quality factor of transmission response up to 2.71/mg/dl. The sensor’s performance has also been tested to detect diabetic hyperosmolar syndrome. The sensor showed a linear shift in resonant frequency with the change in glucose levels, and an R(2) of 0.9976 was obtained by applying regression analysis. Thus, the sensor can be used to monitor glucose in a normal range as well as at extreme levels. Public Library of Science 2022-06-29 /pmc/articles/PMC9242449/ /pubmed/35767587 http://dx.doi.org/10.1371/journal.pone.0269060 Text en © 2022 Qureshi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Qureshi, Suhail Asghar
Abidin, Zuhairiah Zainal
Elamin, N. I. M.
A. Majid, Huda
Ashyap, Adel Y. I.
Nebhen, Jamel
Kamarudin, M. R.
See, Chan Hwang
Abd-Alhameed, R. A.
Glucose level detection using millimetre-wave metamaterial-inspired resonator
title Glucose level detection using millimetre-wave metamaterial-inspired resonator
title_full Glucose level detection using millimetre-wave metamaterial-inspired resonator
title_fullStr Glucose level detection using millimetre-wave metamaterial-inspired resonator
title_full_unstemmed Glucose level detection using millimetre-wave metamaterial-inspired resonator
title_short Glucose level detection using millimetre-wave metamaterial-inspired resonator
title_sort glucose level detection using millimetre-wave metamaterial-inspired resonator
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242449/
https://www.ncbi.nlm.nih.gov/pubmed/35767587
http://dx.doi.org/10.1371/journal.pone.0269060
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