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Immunomodulatory actions of a kynurenine-derived endogenous electrophile

The up-regulation of kynurenine metabolism induces immunomodulatory responses via incompletely understood mechanisms. We report that increases in cellular and systemic kynurenine levels yield the electrophilic derivative kynurenine-carboxyketoalkene (Kyn-CKA), as evidenced by the accumulation of thi...

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Detalles Bibliográficos
Autores principales:	Carreño, Mara, Pires, Maria F., Woodcock, Steven R., Brzoska, Tomasz, Ghosh, Samit, Salvatore, Sonia R., Chang, Fei, Khoo, Nicholas K. H., Dunn, Matthew, Connors, Nora, Yuan, Shuai, Straub, Adam C., Wendell, Stacy G., Kato, Gregory J., Freeman, Bruce A., Ofori-Acquah, Solomon F., Sundd, Prithu, Schopfer, Francisco J., Vitturi, Dario A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242454/ https://www.ncbi.nlm.nih.gov/pubmed/35767602 http://dx.doi.org/10.1126/sciadv.abm9138

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