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Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study

Since 2000, two lineages of influenza B viruses, Victoria and Yamagata, have been circulating at similar frequencies worldwide. Little is known about the circulation of those viruses in Egypt. This study aims to describe the epidemiology of influenza B virus infections in Egypt, 2017–2019. This was...

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Autores principales: Abo Shama, Noura M., Mahmoud, Sara H., Bagato, Ola, AbdElsalam, Elsayed Tarek, Alkhazindar, Maha, Kandeil, Ahmed, McKenzie, Pamela P., Webby, Richard J., Ali, Mohamed A., Kayali, Ghazi, El-Shesheny, Rabeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242516/
https://www.ncbi.nlm.nih.gov/pubmed/35767564
http://dx.doi.org/10.1371/journal.pone.0269321
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author Abo Shama, Noura M.
Mahmoud, Sara H.
Bagato, Ola
AbdElsalam, Elsayed Tarek
Alkhazindar, Maha
Kandeil, Ahmed
McKenzie, Pamela P.
Webby, Richard J.
Ali, Mohamed A.
Kayali, Ghazi
El-Shesheny, Rabeh
author_facet Abo Shama, Noura M.
Mahmoud, Sara H.
Bagato, Ola
AbdElsalam, Elsayed Tarek
Alkhazindar, Maha
Kandeil, Ahmed
McKenzie, Pamela P.
Webby, Richard J.
Ali, Mohamed A.
Kayali, Ghazi
El-Shesheny, Rabeh
author_sort Abo Shama, Noura M.
collection PubMed
description Since 2000, two lineages of influenza B viruses, Victoria and Yamagata, have been circulating at similar frequencies worldwide. Little is known about the circulation of those viruses in Egypt. This study aims to describe the epidemiology of influenza B virus infections in Egypt, 2017–2019. This was performed through a household prospective cohort study on influenza infections among 2400 individuals from five villages. When a study participant had influenza like symptoms, a nasal swab and an oropharyngeal swab were obtained and tested by RT-PCR for influenza B infections. A serum sample was obtained from all participants annually to detect neutralizing antibodies using microneutralization assay. 9.1% of subjects were positive for influenza B viruses during season 2017–2018 mostly among preschoolers and 7.6% were positive during the season 2018–2019 with higher risk in females, potentially due to mothers being infected after contact with their children. The overall seroprevalence among the participants was 53.2% and 52.2% against the Victoria and Yamagata lineages respectively, the majority of seropositive participants were students. Multivariate analysis showed that age and having chronic diseases were the strongest predictors of infection. Our results show that both influenza B lineages circulated between 2017 and 2020 in Egypt almost in equal proportion. Encouraging the uptake of seasonal influenza vaccines is recommended.
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spelling pubmed-92425162022-06-30 Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study Abo Shama, Noura M. Mahmoud, Sara H. Bagato, Ola AbdElsalam, Elsayed Tarek Alkhazindar, Maha Kandeil, Ahmed McKenzie, Pamela P. Webby, Richard J. Ali, Mohamed A. Kayali, Ghazi El-Shesheny, Rabeh PLoS One Research Article Since 2000, two lineages of influenza B viruses, Victoria and Yamagata, have been circulating at similar frequencies worldwide. Little is known about the circulation of those viruses in Egypt. This study aims to describe the epidemiology of influenza B virus infections in Egypt, 2017–2019. This was performed through a household prospective cohort study on influenza infections among 2400 individuals from five villages. When a study participant had influenza like symptoms, a nasal swab and an oropharyngeal swab were obtained and tested by RT-PCR for influenza B infections. A serum sample was obtained from all participants annually to detect neutralizing antibodies using microneutralization assay. 9.1% of subjects were positive for influenza B viruses during season 2017–2018 mostly among preschoolers and 7.6% were positive during the season 2018–2019 with higher risk in females, potentially due to mothers being infected after contact with their children. The overall seroprevalence among the participants was 53.2% and 52.2% against the Victoria and Yamagata lineages respectively, the majority of seropositive participants were students. Multivariate analysis showed that age and having chronic diseases were the strongest predictors of infection. Our results show that both influenza B lineages circulated between 2017 and 2020 in Egypt almost in equal proportion. Encouraging the uptake of seasonal influenza vaccines is recommended. Public Library of Science 2022-06-29 /pmc/articles/PMC9242516/ /pubmed/35767564 http://dx.doi.org/10.1371/journal.pone.0269321 Text en © 2022 Abo Shama et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Abo Shama, Noura M.
Mahmoud, Sara H.
Bagato, Ola
AbdElsalam, Elsayed Tarek
Alkhazindar, Maha
Kandeil, Ahmed
McKenzie, Pamela P.
Webby, Richard J.
Ali, Mohamed A.
Kayali, Ghazi
El-Shesheny, Rabeh
Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study
title Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study
title_full Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study
title_fullStr Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study
title_full_unstemmed Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study
title_short Incidence and neutralizing antibody seroprevalence of influenza B virus in Egypt: Results of a community-based cohort study
title_sort incidence and neutralizing antibody seroprevalence of influenza b virus in egypt: results of a community-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242516/
https://www.ncbi.nlm.nih.gov/pubmed/35767564
http://dx.doi.org/10.1371/journal.pone.0269321
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