NAC1 modulates autoimmunity by suppressing regulatory T cell–mediated tolerance

We report here that nucleus accumbens–associated protein-1 (NAC1), a nuclear factor of the Broad-complex, Tramtrack, Bric-a-brac/poxvirus and zinc finger (BTB/POZ) gene family, is a negative regulator of FoxP3 in regulatory T cells (T(regs)) and a critical determinant of immune tolerance. Phenotypic...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jin-Ming, Ren, Yijie, Kumar, Anil, Xiong, Xiaofang, Das, Jugal Kishore, Peng, Hao-Yun, Wang, Liqing, Ren, Xingcong, Zhang, Yi, Ji, Cheng, Cheng, Yan, Zhang, Li, Alaniz, Robert C., de Figueiredo, Paul, Fang, Deyu, Zhou, Hongwei, Liu, Xiaoqi, Wang, Jianlong, Song, Jianxun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242588/
https://www.ncbi.nlm.nih.gov/pubmed/35767626
http://dx.doi.org/10.1126/sciadv.abo0183

Ejemplares similares

Ejemplares similares