Activation of the human chemokine receptor CX3CR1 regulated by cholesterol

As the only member of the CX3C chemokine receptor subfamily, CX3CR1 binds to its sole endogenous ligand CX3CL1, which shows notable potential as a therapeutic target in atherosclerosis, cancer, and neuropathy. However, the drug development of CX3CR1 is hampered partially by the lack of structural in...

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Detalles Bibliográficos
Autores principales: Lu, Minmin, Zhao, Wenli, Han, Shuo, Lin, Xiaowen, Xu, Tingyu, Tan, Qiuxiang, Wang, Mu, Yi, Cuiying, Chu, Xiaojing, Yang, Weibo, Zhu, Ya, Wu, Beili, Zhao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242592/
https://www.ncbi.nlm.nih.gov/pubmed/35767622
http://dx.doi.org/10.1126/sciadv.abn8048

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