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In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer

Immune checkpoint inhibitors exhibit limited response rates in patients with triple-negative breast cancer (TNBC), suggesting that additional immune escape mechanisms may exist. Here, we performed two-step customized in vivo CRISPR screens targeting disease-related immune genes using different mouse...

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Detalles Bibliográficos
Autores principales:	Ji, Peng, Gong, Yue, Jin, Ming-liang, Wu, Huai-liang, Guo, Lin-Wei, Pei, Yu-Chen, Chai, Wen-Jun, Jiang, Yi-Zhou, Liu, Yin, Ma, Xiao-Yan, Di, Gen-Hong, Hu, Xin, Shao, Zhi-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242595/ https://www.ncbi.nlm.nih.gov/pubmed/35767614 http://dx.doi.org/10.1126/sciadv.abl8247

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