Cargando…
Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma
BACKGROUND: Retinitis pigmentosa (RP) is the most common retinal hereditary dystrophy, which can lead to blindness if it progresses. Similarly, open-angle glaucoma (OAG) is a genetic disorder. The similarities in genetic variants and pathophysiology between RP and OAG have been reported. We sought t...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242799/ https://www.ncbi.nlm.nih.gov/pubmed/35783342 http://dx.doi.org/10.1155/2022/9719095 |
_version_ | 1784738133124841472 |
---|---|
author | Hung, Man-Chen Chen, Yu-Yen |
author_facet | Hung, Man-Chen Chen, Yu-Yen |
author_sort | Hung, Man-Chen |
collection | PubMed |
description | BACKGROUND: Retinitis pigmentosa (RP) is the most common retinal hereditary dystrophy, which can lead to blindness if it progresses. Similarly, open-angle glaucoma (OAG) is a genetic disorder. The similarities in genetic variants and pathophysiology between RP and OAG have been reported. We sought to explore whether patients with RP have a significantly higher risk of OAG development. METHODS: We enrolled patients with RP into the RP group through Taiwan's National Health Insurance Research Database from 2001 to 2013; we included a comparison group of 1 : 4 age- and gender-matched individuals without RP. We performed a Cox regression analysis to estimate the crude and adjusted hazard ratios (HRs) for OAG. We adjusted the following confounders in the Cox regression model: age, gender, diabetes mellitus, hypertension, and chronic kidney disease. RESULTS: We enrolled 6,223 subjects with RP and 24,892 subjects for comparison. The mean age of the cohort was 49.0 ± 18.1 years. The RP group had significantly higher percentages of diabetes mellitus, hypertension, and hyperlipidaemia. The cumulative incidence of OAG in patients with RP was 1.57%; this was significantly higher than that in the comparison group (0.58%, p < 0.0001). On univariate Cox regression analysis, the hazard of OAG development was significantly greater in the RP group than in the comparison group with an unadjusted HR of 2.86 (95% confidence interval, 2.21–3.70). The increased risk persisted after adjusting for confounders (adjusted HR = 2.86; 95% CI, 2.21–3.70). CONCLUSIONS: This nationwide population-based cohort study showed that people with RP are at a significantly greater risk of developing OAG than individuals without it. |
format | Online Article Text |
id | pubmed-9242799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-92427992022-06-30 Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma Hung, Man-Chen Chen, Yu-Yen J Ophthalmol Research Article BACKGROUND: Retinitis pigmentosa (RP) is the most common retinal hereditary dystrophy, which can lead to blindness if it progresses. Similarly, open-angle glaucoma (OAG) is a genetic disorder. The similarities in genetic variants and pathophysiology between RP and OAG have been reported. We sought to explore whether patients with RP have a significantly higher risk of OAG development. METHODS: We enrolled patients with RP into the RP group through Taiwan's National Health Insurance Research Database from 2001 to 2013; we included a comparison group of 1 : 4 age- and gender-matched individuals without RP. We performed a Cox regression analysis to estimate the crude and adjusted hazard ratios (HRs) for OAG. We adjusted the following confounders in the Cox regression model: age, gender, diabetes mellitus, hypertension, and chronic kidney disease. RESULTS: We enrolled 6,223 subjects with RP and 24,892 subjects for comparison. The mean age of the cohort was 49.0 ± 18.1 years. The RP group had significantly higher percentages of diabetes mellitus, hypertension, and hyperlipidaemia. The cumulative incidence of OAG in patients with RP was 1.57%; this was significantly higher than that in the comparison group (0.58%, p < 0.0001). On univariate Cox regression analysis, the hazard of OAG development was significantly greater in the RP group than in the comparison group with an unadjusted HR of 2.86 (95% confidence interval, 2.21–3.70). The increased risk persisted after adjusting for confounders (adjusted HR = 2.86; 95% CI, 2.21–3.70). CONCLUSIONS: This nationwide population-based cohort study showed that people with RP are at a significantly greater risk of developing OAG than individuals without it. Hindawi 2022-06-22 /pmc/articles/PMC9242799/ /pubmed/35783342 http://dx.doi.org/10.1155/2022/9719095 Text en Copyright © 2022 Man-Chen Hung and Yu-Yen Chen. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hung, Man-Chen Chen, Yu-Yen Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma |
title | Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma |
title_full | Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma |
title_fullStr | Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma |
title_full_unstemmed | Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma |
title_short | Patients with Retinitis Pigmentosa May Have a Higher Risk of Developing Open-Angle Glaucoma |
title_sort | patients with retinitis pigmentosa may have a higher risk of developing open-angle glaucoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242799/ https://www.ncbi.nlm.nih.gov/pubmed/35783342 http://dx.doi.org/10.1155/2022/9719095 |
work_keys_str_mv | AT hungmanchen patientswithretinitispigmentosamayhaveahigherriskofdevelopingopenangleglaucoma AT chenyuyen patientswithretinitispigmentosamayhaveahigherriskofdevelopingopenangleglaucoma |