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Mechanism of replication origin melting nucleated by CMG helicase assembly

The activation of eukaryotic origins of replication occurs in temporally separated steps to ensure that chromosomes are copied only once per cell cycle. First, the MCM helicase is loaded onto duplex DNA as an inactive double hexamer. Activation occurs after the recruitment of a set of firing factors...

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Detalles Bibliográficos
Autores principales:	Lewis, Jacob S., Gross, Marta H., Sousa, Joana, Henrikus, Sarah S., Greiwe, Julia F., Nans, Andrea, Diffley, John F. X., Costa, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242855/ https://www.ncbi.nlm.nih.gov/pubmed/35705812 http://dx.doi.org/10.1038/s41586-022-04829-4

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