Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography

This work reports about a screening of four adsorbents with different polarity employed for the separation of the main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect of polarity and type of interaction mechanisms of the adsorbents (name...

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Detalles Bibliográficos
Autores principales: De Luca, Chiara, Buratti, Alessandro, Krauke, Yannick, Stephan, Svea, Monks, Kate, Brighenti, Virginia, Pellati, Federica, Cavazzini, Alberto, Catani, Martina, Felletti, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242945/
https://www.ncbi.nlm.nih.gov/pubmed/35146546
http://dx.doi.org/10.1007/s00216-021-03862-y
Descripción
Sumario:This work reports about a screening of four adsorbents with different polarity employed for the separation of the main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect of polarity and type of interaction mechanisms of the adsorbents (namely Si-, CN-, Diol-, and NH(2)-based SPs) on retention has been investigated under a variety of conditions either by using different combinations of apolar solvents (heptane or hexane) and alcohols (ethanol or isopropanol). The columns have also been employed for the separation of a real cannabis sample. [Figure: see text]

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