Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography

This work reports about a screening of four adsorbents with different polarity employed for the separation of the main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect of polarity and type of interaction mechanisms of the adsorbents (name...

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Autores principales: De Luca, Chiara, Buratti, Alessandro, Krauke, Yannick, Stephan, Svea, Monks, Kate, Brighenti, Virginia, Pellati, Federica, Cavazzini, Alberto, Catani, Martina, Felletti, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242945/
https://www.ncbi.nlm.nih.gov/pubmed/35146546
http://dx.doi.org/10.1007/s00216-021-03862-y
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author De Luca, Chiara
Buratti, Alessandro
Krauke, Yannick
Stephan, Svea
Monks, Kate
Brighenti, Virginia
Pellati, Federica
Cavazzini, Alberto
Catani, Martina
Felletti, Simona
author_facet De Luca, Chiara
Buratti, Alessandro
Krauke, Yannick
Stephan, Svea
Monks, Kate
Brighenti, Virginia
Pellati, Federica
Cavazzini, Alberto
Catani, Martina
Felletti, Simona
author_sort De Luca, Chiara
collection PubMed
description This work reports about a screening of four adsorbents with different polarity employed for the separation of the main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect of polarity and type of interaction mechanisms of the adsorbents (namely Si-, CN-, Diol-, and NH(2)-based SPs) on retention has been investigated under a variety of conditions either by using different combinations of apolar solvents (heptane or hexane) and alcohols (ethanol or isopropanol). The columns have also been employed for the separation of a real cannabis sample. [Figure: see text]
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spelling pubmed-92429452022-07-01 Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography De Luca, Chiara Buratti, Alessandro Krauke, Yannick Stephan, Svea Monks, Kate Brighenti, Virginia Pellati, Federica Cavazzini, Alberto Catani, Martina Felletti, Simona Anal Bioanal Chem Research Paper This work reports about a screening of four adsorbents with different polarity employed for the separation of the main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect of polarity and type of interaction mechanisms of the adsorbents (namely Si-, CN-, Diol-, and NH(2)-based SPs) on retention has been investigated under a variety of conditions either by using different combinations of apolar solvents (heptane or hexane) and alcohols (ethanol or isopropanol). The columns have also been employed for the separation of a real cannabis sample. [Figure: see text] Springer Berlin Heidelberg 2022-02-10 2022 /pmc/articles/PMC9242945/ /pubmed/35146546 http://dx.doi.org/10.1007/s00216-021-03862-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Paper
De Luca, Chiara
Buratti, Alessandro
Krauke, Yannick
Stephan, Svea
Monks, Kate
Brighenti, Virginia
Pellati, Federica
Cavazzini, Alberto
Catani, Martina
Felletti, Simona
Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
title Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
title_full Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
title_fullStr Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
title_full_unstemmed Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
title_short Investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
title_sort investigating the effect of polarity of stationary and mobile phases on retention of cannabinoids in normal phase liquid chromatography
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242945/
https://www.ncbi.nlm.nih.gov/pubmed/35146546
http://dx.doi.org/10.1007/s00216-021-03862-y
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