Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant

BACKGROUND: The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. METHODS: Based on viral mic...

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Autores principales: Campos, Guilherme R. F., Almeida, Nathalie Bonatti Franco, Filgueiras, Priscilla Soares, Corsini, Camila Amormino, Gomes, Sarah Vieira Contin, de Miranda, Daniel Alvim Pena, de Assis, Jéssica Vieira, de Souza Silva, Thaís Bárbara, Alves, Pedro Augusto, da Rocha Fernandes, Gabriel, de Oliveira, Jaquelline Germano, Rahal, Paula, Grenfell, Rafaella Fortini Queiroz, Nogueira, Maurício L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242982/
https://www.ncbi.nlm.nih.gov/pubmed/35784447
http://dx.doi.org/10.1038/s43856-022-00141-4
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author Campos, Guilherme R. F.
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
de Miranda, Daniel Alvim Pena
de Assis, Jéssica Vieira
de Souza Silva, Thaís Bárbara
Alves, Pedro Augusto
da Rocha Fernandes, Gabriel
de Oliveira, Jaquelline Germano
Rahal, Paula
Grenfell, Rafaella Fortini Queiroz
Nogueira, Maurício L.
author_facet Campos, Guilherme R. F.
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
de Miranda, Daniel Alvim Pena
de Assis, Jéssica Vieira
de Souza Silva, Thaís Bárbara
Alves, Pedro Augusto
da Rocha Fernandes, Gabriel
de Oliveira, Jaquelline Germano
Rahal, Paula
Grenfell, Rafaella Fortini Queiroz
Nogueira, Maurício L.
author_sort Campos, Guilherme R. F.
collection PubMed
description BACKGROUND: The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. METHODS: Based on viral microneutralization assays, we evaluated in 90 individuals the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. RESULTS: Here we show that the percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 16.6% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times. CONCLUSIONS: These results indicate a positive impact of this vaccine combination in the serological immune response against SARS-CoV-2 Omicron variant.
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spelling pubmed-92429822022-06-30 Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant Campos, Guilherme R. F. Almeida, Nathalie Bonatti Franco Filgueiras, Priscilla Soares Corsini, Camila Amormino Gomes, Sarah Vieira Contin de Miranda, Daniel Alvim Pena de Assis, Jéssica Vieira de Souza Silva, Thaís Bárbara Alves, Pedro Augusto da Rocha Fernandes, Gabriel de Oliveira, Jaquelline Germano Rahal, Paula Grenfell, Rafaella Fortini Queiroz Nogueira, Maurício L. Commun Med (Lond) Article BACKGROUND: The emergence of the new SARS-CoV-2 Omicron variant, which is known to have a large number of mutations when compared to other variants, brought to light the concern about vaccine escape, especially from the neutralization by antibodies induced by vaccination. METHODS: Based on viral microneutralization assays, we evaluated in 90 individuals the impact on antibody neutralization induction, against Omicron variant, by a booster dose of BNT162b2 mRNA vaccine after the CoronaVac primary vaccination scheme. RESULTS: Here we show that the percentage of seroconverted individuals 30 and 60 days after CoronaVac scheme was 16.6% and 10%, respectively. After booster dose administration, the seroconvertion rate increased to 76.6%. The neutralization mean titer against Omicron in the CoronaVac protocol decreased over time, but after the booster dose, the mean titer increased 43.1 times. CONCLUSIONS: These results indicate a positive impact of this vaccine combination in the serological immune response against SARS-CoV-2 Omicron variant. Nature Publishing Group UK 2022-06-29 /pmc/articles/PMC9242982/ /pubmed/35784447 http://dx.doi.org/10.1038/s43856-022-00141-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Campos, Guilherme R. F.
Almeida, Nathalie Bonatti Franco
Filgueiras, Priscilla Soares
Corsini, Camila Amormino
Gomes, Sarah Vieira Contin
de Miranda, Daniel Alvim Pena
de Assis, Jéssica Vieira
de Souza Silva, Thaís Bárbara
Alves, Pedro Augusto
da Rocha Fernandes, Gabriel
de Oliveira, Jaquelline Germano
Rahal, Paula
Grenfell, Rafaella Fortini Queiroz
Nogueira, Maurício L.
Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant
title Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant
title_full Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant
title_fullStr Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant
title_full_unstemmed Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant
title_short Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant
title_sort booster dose of bnt162b2 after two doses of coronavac improves neutralization of sars-cov-2 omicron variant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242982/
https://www.ncbi.nlm.nih.gov/pubmed/35784447
http://dx.doi.org/10.1038/s43856-022-00141-4
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