Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor

Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-associated insulin resistance remains unknown. Here, we identify membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) as a central regulator of insulin sensitivity during ageing. Ageing promotes MMP14...

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Detalles Bibliográficos
Autores principales: Guo, Xuanming, Asthana, Pallavi, Gurung, Susma, Zhang, Shuo, Wong, Sheung Kin Ken, Fallah, Samane, Chow, Chi Fung Willis, Che, Sijia, Zhai, Lixiang, Wang, Zening, Ge, Xin, Jiang, Zhixin, Wu, Jiayan, Zhang, Yijing, Wu, Xiaoyu, Xu, Keyang, Lin, Cheng Yuan, Kwan, Hiu Yee, Lyu, Aiping, Zhou, Zhongjun, Bian, Zhao-Xiang, Wong, Hoi Leong Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242991/
https://www.ncbi.nlm.nih.gov/pubmed/35768470
http://dx.doi.org/10.1038/s41467-022-31563-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9242991/
https://www.ncbi.nlm.nih.gov/pubmed/35768470
http://dx.doi.org/10.1038/s41467-022-31563-2

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