Overexpression of satellite RNAs in heterochromatin induces chromosomal instability and reflects drug sensitivity in mouse cancer cells

Overexpression of satellite RNAs in heterochromatin induces chromosomal instability (CIN) through the DNA damage response and cell cycle checkpoint activation. Although satellite RNAs may be therapeutic targets, the associated mechanisms underlying drug sensitivity are unknown. Here, we determined w...

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Detalles Bibliográficos
Autores principales: Tamaki, Sawako, Suzuki, Koichi, Abe, Iku, Endo, Yuhei, Kakizawa, Nao, Watanabe, Fumiaki, Saito, Masaaki, Tsujinaka, Shingo, Miyakura, Yasuyuki, Ohta, Satoshi, Tago, Kenji, Yanagisawa, Ken, Konishi, Fumio, Rikiyama, Toshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243030/
https://www.ncbi.nlm.nih.gov/pubmed/35768614
http://dx.doi.org/10.1038/s41598-022-15071-3

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