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Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment

OBJECTIVE: To assess associations of single and combined exposures to lead and stress during different stages of pregnancy with offspring neurodevelopment. METHODS: We measured prenatal lead (maternal blood-lead in early-pregnancy and umbilical-cord-blood-lead) and maternal stress levels in Shanghai...

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Autores principales: Guo, Xiangrong, Jiang, Shiwei, Xu, Jian, Tian, Ying, Ouyang, Fengxiu, Yu, Xiaodan, Liu, Junxia, Yan, Chonghuai, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243049/
https://www.ncbi.nlm.nih.gov/pubmed/35753194
http://dx.doi.org/10.1016/j.dcn.2022.101124
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author Guo, Xiangrong
Jiang, Shiwei
Xu, Jian
Tian, Ying
Ouyang, Fengxiu
Yu, Xiaodan
Liu, Junxia
Yan, Chonghuai
Zhang, Jun
author_facet Guo, Xiangrong
Jiang, Shiwei
Xu, Jian
Tian, Ying
Ouyang, Fengxiu
Yu, Xiaodan
Liu, Junxia
Yan, Chonghuai
Zhang, Jun
author_sort Guo, Xiangrong
collection PubMed
description OBJECTIVE: To assess associations of single and combined exposures to lead and stress during different stages of pregnancy with offspring neurodevelopment. METHODS: We measured prenatal lead (maternal blood-lead in early-pregnancy and umbilical-cord-blood-lead) and maternal stress levels in Shanghai-Birth-Cohort from 2013 to 2016. Maternal stress was assessed using Center-for-Epidemiological-Studies-Depression-Scale and Self-Rating-Anxiety-Scale during mid-pregnancy. The Ages-Stages-Questionnaires-3 (at 6/12-months-of-age) and Bayley-III (at 24-months-of-age) were both used to assess neurodevelopment. RESULTS: A total of 2132 mother-child pairs with both prenatal lead and stress measurements were included. The geometric-means of blood-lead in early-pregnancy and cord-blood-lead were 1.46 μg/dL and 1.33 μg/dL, respectively. Among the study women, 1.89 % and 0.14 % were screened positive for depression and anxiety. Adjusting for related confounders, the combined exposures had stronger adverse associations with offspring social-emotional skills than single exposures; and the combined exposure in early-pregnancy was associated with greater neurodevelopmental differences than combined exposure around-birth, especially in social-emotion at 24 months-of-age [β (95 %CI): − 10.48(−17.42, −3.54) vs. − 5.95(−11.53, −0.36)]. CONCLUSIONS: Both single and combined prenatal exposures to lead/stress impaired infant neuro-development, and the effects of combined exposure may be more profound than single exposures. Combined exposure in early-pregnancy may be associated with worse neurodevelopmental outcomes than combined exposure around-birth, especially in social-emotional development.
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spelling pubmed-92430492022-07-01 Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment Guo, Xiangrong Jiang, Shiwei Xu, Jian Tian, Ying Ouyang, Fengxiu Yu, Xiaodan Liu, Junxia Yan, Chonghuai Zhang, Jun Dev Cogn Neurosci Original Research OBJECTIVE: To assess associations of single and combined exposures to lead and stress during different stages of pregnancy with offspring neurodevelopment. METHODS: We measured prenatal lead (maternal blood-lead in early-pregnancy and umbilical-cord-blood-lead) and maternal stress levels in Shanghai-Birth-Cohort from 2013 to 2016. Maternal stress was assessed using Center-for-Epidemiological-Studies-Depression-Scale and Self-Rating-Anxiety-Scale during mid-pregnancy. The Ages-Stages-Questionnaires-3 (at 6/12-months-of-age) and Bayley-III (at 24-months-of-age) were both used to assess neurodevelopment. RESULTS: A total of 2132 mother-child pairs with both prenatal lead and stress measurements were included. The geometric-means of blood-lead in early-pregnancy and cord-blood-lead were 1.46 μg/dL and 1.33 μg/dL, respectively. Among the study women, 1.89 % and 0.14 % were screened positive for depression and anxiety. Adjusting for related confounders, the combined exposures had stronger adverse associations with offspring social-emotional skills than single exposures; and the combined exposure in early-pregnancy was associated with greater neurodevelopmental differences than combined exposure around-birth, especially in social-emotion at 24 months-of-age [β (95 %CI): − 10.48(−17.42, −3.54) vs. − 5.95(−11.53, −0.36)]. CONCLUSIONS: Both single and combined prenatal exposures to lead/stress impaired infant neuro-development, and the effects of combined exposure may be more profound than single exposures. Combined exposure in early-pregnancy may be associated with worse neurodevelopmental outcomes than combined exposure around-birth, especially in social-emotional development. Elsevier 2022-06-16 /pmc/articles/PMC9243049/ /pubmed/35753194 http://dx.doi.org/10.1016/j.dcn.2022.101124 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Guo, Xiangrong
Jiang, Shiwei
Xu, Jian
Tian, Ying
Ouyang, Fengxiu
Yu, Xiaodan
Liu, Junxia
Yan, Chonghuai
Zhang, Jun
Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment
title Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment
title_full Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment
title_fullStr Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment
title_full_unstemmed Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment
title_short Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment
title_sort effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243049/
https://www.ncbi.nlm.nih.gov/pubmed/35753194
http://dx.doi.org/10.1016/j.dcn.2022.101124
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