CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway

Accumulating evidence has demonstrated that carbohydrate response element binding protein (CHREBP) has a crucial function in tumor pathology. In this study, we found CHREBP downregulation in gastric cancer (GC) tissues, and CHREBP was determined to be an independent diagnostic marker of GC. The down...

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Autores principales: Zhang, Jianming, Zhang, Jing, Fu, Zhongmao, Zhang, Yuan, Luo, Zai, Zhang, Pengshan, Xu, Yitian, Huang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243070/
https://www.ncbi.nlm.nih.gov/pubmed/35768405
http://dx.doi.org/10.1038/s41420-022-01079-1
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author Zhang, Jianming
Zhang, Jing
Fu, Zhongmao
Zhang, Yuan
Luo, Zai
Zhang, Pengshan
Xu, Yitian
Huang, Chen
author_facet Zhang, Jianming
Zhang, Jing
Fu, Zhongmao
Zhang, Yuan
Luo, Zai
Zhang, Pengshan
Xu, Yitian
Huang, Chen
author_sort Zhang, Jianming
collection PubMed
description Accumulating evidence has demonstrated that carbohydrate response element binding protein (CHREBP) has a crucial function in tumor pathology. In this study, we found CHREBP downregulation in gastric cancer (GC) tissues, and CHREBP was determined to be an independent diagnostic marker of GC. The downregulation of CHREBP promoted cell proliferation and inhibited apoptosis. Moreover, the level of cyclin D1 was significantly correlated with CHREBP expression in GC and paracancerous normal samples. In addition, CHREBP transcriptionally inhibited cyclin D1 expression in GC cells. Tumor suppressor activity of CHREBP could be affected by the upregulation of cyclin D1. In summary, CHREBP was found to be an independent diagnostic marker of GC and to influence GC growth and apoptosis via targeting the cyclin D1-Rb-E2F1 pathway.
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spelling pubmed-92430702022-07-01 CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway Zhang, Jianming Zhang, Jing Fu, Zhongmao Zhang, Yuan Luo, Zai Zhang, Pengshan Xu, Yitian Huang, Chen Cell Death Discov Article Accumulating evidence has demonstrated that carbohydrate response element binding protein (CHREBP) has a crucial function in tumor pathology. In this study, we found CHREBP downregulation in gastric cancer (GC) tissues, and CHREBP was determined to be an independent diagnostic marker of GC. The downregulation of CHREBP promoted cell proliferation and inhibited apoptosis. Moreover, the level of cyclin D1 was significantly correlated with CHREBP expression in GC and paracancerous normal samples. In addition, CHREBP transcriptionally inhibited cyclin D1 expression in GC cells. Tumor suppressor activity of CHREBP could be affected by the upregulation of cyclin D1. In summary, CHREBP was found to be an independent diagnostic marker of GC and to influence GC growth and apoptosis via targeting the cyclin D1-Rb-E2F1 pathway. Nature Publishing Group UK 2022-06-29 /pmc/articles/PMC9243070/ /pubmed/35768405 http://dx.doi.org/10.1038/s41420-022-01079-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Jianming
Zhang, Jing
Fu, Zhongmao
Zhang, Yuan
Luo, Zai
Zhang, Pengshan
Xu, Yitian
Huang, Chen
CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway
title CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway
title_full CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway
title_fullStr CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway
title_full_unstemmed CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway
title_short CHREBP suppresses gastric cancer progression via the cyclin D1-Rb-E2F1 pathway
title_sort chrebp suppresses gastric cancer progression via the cyclin d1-rb-e2f1 pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243070/
https://www.ncbi.nlm.nih.gov/pubmed/35768405
http://dx.doi.org/10.1038/s41420-022-01079-1
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