Quantitative systems pharmacology modeling sheds light into the dose response relationship of a trispecific T cell engager in multiple myeloma

In relapsed and refractory multiple myeloma (RRMM), there are few treatment options once patients progress from the established standard of care. Several bispecific T-cell engagers (TCE) are in clinical development for multiple myeloma (MM), designed to promote T-cell activation and tumor killing by...

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Detalles Bibliográficos
Autores principales: Abrams, R. E., Pierre, K., El-Murr, N., Seung, E., Wu, L., Luna, E., Mehta, R., Li, J., Larabi, K., Ahmed, M., Pelekanou, V., Yang, Z.-Y., van de Velde, H., Stamatelos, S. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243109/
https://www.ncbi.nlm.nih.gov/pubmed/35768621
http://dx.doi.org/10.1038/s41598-022-14726-5

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