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Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

OBJECTIVE: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans. During the adrenergic stimulation of brown adipocytes, free fatty acids generated from lip...

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Detalles Bibliográficos
Autores principales:	Cavalieri, Riccardo, Hazebroek, Marlou Klein, Cotrim, Camila A., Lee, Yang, Kunji, Edmund R.S., Jastroch, Martin, Keipert, Susanne, Crichton, Paul G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243162/ https://www.ncbi.nlm.nih.gov/pubmed/35691529 http://dx.doi.org/10.1016/j.molmet.2022.101526

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