Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding

Rhesus monkeys have evolved MHC-encoded class I allomorphs such as Mamu-B∗098 that are capable of binding N-myristoylated short lipopeptides rather than conventional long peptides; however, it remains unknown whether such antigen-binding molecules exist in other species, including humans. We herein...

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Detalles Bibliográficos
Autores principales: Asa, Minori, Morita, Daisuke, Kuroha, Jin, Mizutani, Tatsuaki, Mori, Naoki, Mikami, Bunzo, Sugita, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243169/
https://www.ncbi.nlm.nih.gov/pubmed/35667438
http://dx.doi.org/10.1016/j.jbc.2022.102100

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